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ProteomicsPhenotypic rescue of a novel heterozygous HARS L400F variant associated with Charcot-Marie-Tooth disease
Cytoplasmic histidyl-tRNA synthetase (HARS1) is an essential protein in translation ligating histidine to its cognate tRNAHis. HARS1 is one of several aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth Disease, an axonal peripheral neuropathy. Advances in genetic testing identify many var...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-02 | PXD067079 | Pride
Histidyl-trna synthetase Protein translation Charcot-marie-tooth disease 
ProteomicsProteomic changes in HepaRG cells exposed to mycotoxins, part 2
Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after 24 hour expousre and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD006267 | Pride
Mycotoxin 
MetabolomicsUntargeted metabolomics profiling reveals exercise intensity-dependent alterations in Thoroughbred racehorses’ plasma after routine conditioning sessions

Thoroughbred (TB) racehorses are subjected to rigorous conditioning programs involving exercise sessions of various types, distances and intensities. These programs aim to optimize both their physical and mental capabilities, which are essential to achieve maximal performance. Conventional invest...

2024-01-16 | MTBLS8285 | MetaboLights
UnknownHDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D).
Not available
S-EPMC8849597 | biostudies-literature
UnknownDisease Progression in Charcot-Marie-Tooth Disease Related to MPZ Mutations: A Longitudinal Study.
Not available
S-EPMC9977145 | biostudies-literature
TranscriptomicsTranscription profiling of human macrophages from ankylosing spondylitis patients reveals interferon-gamma dysregulation
OBJECTIVE: To determine whether macrophages, a type of cell implicated in the pathogenesis of ankylosing spondylitis (AS), exhibit a characteristic gene expression pattern. METHODS: Macrophages were derived from the peripheral blood of 8 AS patients (median disease duration 13 years [range <1-43 yea...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11886 | biostudies-arrayexpress
ProteomicsProteomic changes in HepaRG cells exposed to mycotoxins
Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after only 1h exposure and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry (LC-MS...
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD005840 | Pride
Co-exposure Hepatocytes Human Deoxynivalenol Zearalenone Lc-ms/ms 
UnknownThe imprinted gene Pw1/Peg3 regulates skeletal muscle growth, satellite cell metabolic state, and self-renewal.
Not available
S-EPMC6168517 | biostudies-literature
ProteomicsIdentification of thioredoxin targets in Chlamydomonas reinhardtii using an affinity purification approach
Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms. In this context, the small ubiquitous oxido-reductase thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins. Recent redox proteomi...
ORGANISM(S): Chlamydomonas reinhardtii 
2017-07-28 | PXD006097 | Pride
Chlamydomonas reinhardtii Redox proteomics Disulfide bonds Thioredoxin targets Redox regulation 
MetabolomicsSeasonal and day/night variations of microbial metabolic functioning in simulated cloud water

Microorganisms maintain metabolic activity in clouds, with recognized impacts on chemical reactivity by contributing to the processing of small organic compounds, radicals and their precursors. However, the conditions in clouds can be highly contrasted (temperature, light, etc), and it remains un...

2026-02-12 | MTBLS12281 | MetaboLights
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