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MetabolomicsRare and common genetic determinants of metabolic individuality and their effects on human health (EPIC-Norfolk study assays)

Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS833 | MetaboLights
ProteomicsElectron-based dissociation is needed for O-glycopeptides derived from OpeRATOR proteolysis
The recently described O-glycoprotease OpeRATOR presents exciting opportunities for O-glycoproteomics. This bacterial enzyme purified from A. muciniphila cleaves N-terminally to serine and threonine residues that are modified with (preferably asialylated) O-glycans, providing orthogonal cleavage rel...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-11-03 | PXD020077 | Pride
Glycoproteomics O-glycosites Operator Protease Electron transfer dissociation 
TranscriptomicsTranscription profiling of human monozygotic twins discordant for bipolar disorder
To identify genes dysregulated in bipolar disorder (BD1) we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls we compared expression profiles in lymphoblastoid cell lines from monozygotic tw...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7036 | biostudies-arrayexpress
ProteomicsImprovements in glycoproteomics through architecture changes to the Orbitrap Tribrid MS platform
Hardware changes introduced on the Orbitrap Ascend MultiOmics Tribrid MS include dual ion routing multipoles (IRMs) that can enable parallelized accumulation, dissociation, and Orbitrap mass analysis of three separate ion populations. The balance between these instrument functions is especially impo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-14 | PXD058153 | Pride
N-glycopeptides Fragmentation Glycoproteomics Tandem mass spectrometry O-glycopeptides Electron transfer dissociation 
TranscriptomicsshRNA profiling of human Colo16 cells knocked down for Downstreams of hnRNP A2
Limited knowledge of the downstream targets of hnRNP A2/B1 has, however, precluded a clear understanding of their roles in cancer cell growth. To define the pathways in which this protein acts we have now carried out microarray experiments with total RNA from Colo16 epithelial cells transfected with...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-11865 | biostudies-arrayexpress
Unknown#COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol.
Not available
S-EPMC8609898 | biostudies-literature
MetabolomicsMetabolomics analysis reveals the participation of efflux pumps and ornithine in the response of Pseudomonas putida DOT-T1E cells to challenge with propranolol
Efflux pumps are critically important membrane components that play a crucial role in strain tolerance in Pseudomonas putida to antibiotics and aromatic hydrocarbons that result in these toxicants being expelled from the bacteria. Here, the effect of propranolol on P. putida was examined by sudden a...
2016-08-23 | MTBLS320 | MetaboLights
UnknownCabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial.
Not available
S-EPMC4110249 | biostudies-literature
TranscriptomicsRemission in Polyarticular Juvenile Idiopathic Arthritis
Identify biomarkers to predict response to therapy in polyarticular juvenile idiopathic arthritis (JIA) using gene expression microarrays. 42 samples from 13 controls, 14 active patients, 9 patients in clinical remission with medication (CRM), and 6 patients in clinical remission without medication ...
ORGANISM(S): Homo sapiens 
2009-04-13 | E-GEOD-15645 | biostudies-arrayexpress
UnknownCabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: results of a phase II nonrandomized expansion study.
Not available
S-EPMC4383838 | biostudies-literature
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