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TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
TranscriptomicsA methyl-deviator epigenotype of estrogen-receptor-positive breast carcinoma is associated with malignant biology
We broadly profiled DNA methylation in breast cancers (n=351) and benign parenchyma (n=47) for correspondence with disease phenotype using formalin-fixed paraffin-embedded (FFPE) diagnostic surgical pathology specimens. Exploratory analysis revealed a distinctive primary invasive carcinoma subclass ...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-29428 | biostudies-arrayexpress
TranscriptomicsArray CGH-based Characterization of Genetic Alterations in Pulmonary Neuroendocrine Tumors
The goal of this study was to characterize and classify pulmonary neuroendocrine tumors based on Array Comparative Genomic Hybridization (aCGH). Using aCGH, we performed karyotype analysis of 33 small cell lung cancer (SCLC) tumors, 13 SCLC cell lines, 19 bronchial carcinoids, and 9 gastrointestinal...
ORGANISM(S): Homo sapiens 
2010-04-22 | E-GEOD-21468 | biostudies-arrayexpress
UnknownThe mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function.
Not available
S-EPMC4262609 | biostudies-literature
UnknownHematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey.
Not available
S-EPMC7046837 | biostudies-literature
UnknownUganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.
Not available
S-EPMC7202134 | biostudies-literature
UnknownDrosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.
Not available
S-EPMC4426361 | biostudies-literature
UnknownFacilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience.
Not available
S-EPMC7048401 | biostudies-literature
UnknownGene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.
Not available
S-EPMC3951943 | biostudies-literature
UnknownDiscovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Not available
S-EPMC7610439 | biostudies-literature
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