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TranscriptomicsTranscriptome profiling of dedifferentiating smooth muscle cells from mouse aorta and bladder
Smooth muscle cells (SMCs) are important in a number of physiological systems and organs, including the cardiovascular system. The hallmark property of differentiated SMCs is the ability to contract, but contractile SMCs themselves show a range of phenotypes allowing prolonged tonic contraction in v...
ORGANISM(S): Mus musculus 
2016-07-01 | E-MTAB-4841 | biostudies-arrayexpress
Metabolomics2 lines of pulmonary artery smooth muscle cells metabolic profile (122 vs 3633C central metabolic profile)
Not available
ORGANISM(S): Ovis aries 
ST000180 | MetabolomicsWorkbench
TranscriptomicsRNA-seq identifies novel lncRNAs involved in vascular smooth muscle cell proliferation
Smooth muscle cell (SMC) phenotypic switching from a contractile to a synthetic state is implicated in diverse vascular pathologies, including neointimal formation. This study was designed to identify lncRNAs that may play a role in vascular pathologies. Primary smooth muscle cells cultured from sur...
ORGANISM(S): Homo sapiens 
2016-05-18 | E-GEOD-69637 | biostudies-arrayexpress
TranscriptomicsStretch-dependent genes in vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-60447 | biostudies-arrayexpress
TranscriptomicsA new approach for the study of lung smooth muscle phenotypes and its application in asthma
We developed a new method for the isolation of bronchial smooth muscle cells. This method is built upon a double fluorescent mouse SMA-GFP;NG2-DsRed and cell sorting. Using this method, we isolated bronchial smooth muscle cells from control and asthmatic C57BL/6J mice for gene profiling. Double fluo...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-45723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat A7r5 vascular smooth muscle cells over-expressing glucose transporter
Hypothesis: Overexpression of the GLUT1 facilitative glucose transporter, in A7r5 vascular smooth muscle cells, is sufficient and/or necessary to induce alterations in gene expression which influence apoptosis, growth, and proliferation. Experiment Overall Design: Scientific Approach: A7r5 rat emb...
ORGANISM(S): Rattus norvegicus 
2009-11-07 | E-GEOD-15713 | biostudies-arrayexpress
TranscriptomicsEffects of knockdown of ROCK1 and ZIPK on gene expression in cultured human vascular smooth muscle cells
Rho-associated kinase (ROCK) and zipper-interacting protein kinase (ZIPK) have been implicated in diverse physiological functions, including smooth muscle contraction, cell proliferation, cell adhesion, apoptosis, cell migration and inflammation. Many aspects of regulation via ROCK and ZIPK, however...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-56819 | biostudies-arrayexpress
TranscriptomicsSphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells
Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimu...
ORGANISM(S): Homo sapiens 
2015-06-18 | E-GEOD-58657 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human aortic smooth muscle cells exposed to hypoxia
Systemic arterial smooth muscle cells are exposed to a broad range of oxygen concentrations under physiological conditions. Hypoxia can modulate the proliferative response of smooth muscle cells leading to speculation about its role in vasculogenesis, vascular remodelling and the pathogenesis of ar...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4725 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and Hey2 knockout mouse aortic smooth muscle cells treated with PDGF for different durations to identify differentially expressed transcripts.
The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expr...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6526 | biostudies-arrayexpress
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