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ProteomicsG Protein GalphaQ Subunits Engage Targets in the Nucleus Involved in Chromatin Remodeling and RNA Splicing
G𝛼q is a critical mediator of cell and tissue responses to stimulation of Gq-coupled receptors that regulate PLCbeta and RhoGEFs. To identify novel G𝛼q signaling partners, we performed a proximity labeling proteomic screen in HEK293A cells using TurboID-tagged GalphaQ. Top GalphaQ(Q209L) enriched ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD071839 | Pride
G protein G protein-coupled receptor Proximity labeling Gq Nucleus Chromatin 
ProteomicsStabilization of Interdomain Interactions in G protein α Subunits as a Determinant of Gαi Subtype Signaling Specificity
Highly homologous members of the Gαi family, Gαi1-3, have distinct tissue distributions and physiological functions, yet their biochemical and functional properties are very similar. We recently identified PDZ-RhoGEF (PRG) as a novel Gαi1 effector that is poorly activated by Gαi2. In a proteomic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD050824 | Pride
Heterotrimeric g protein Proximity labeling Mass spectrometry Structure. G protein-coupled receptor Effector coupling Rho gef Domain interactions Alpha subunits 
ProteomicsA Network G Protein Gai Signaling Partners is Revealed by Proximity Labeling Proteomics and Includes PDZ-RhoGEF
G protein-coupled receptors (GPCRs) that couple to the Gi family of G proteins are key regulators of cell and tissue physiology. Our previous work has revealed new roles for Gαi in regulating the migration of neutrophils and fibrosarcoma cells downstream of activated chemoattractant receptors. We us...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD027905 | Pride
Gαi proteins Proximity labeling Pdz-rhogef Cell-migration Interactome Mass spectrometry Gpcr signaling 
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