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ProteomicsIntegrin beta 3 regulates cellular senescence by activating the TGFβ pathway
Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanism(s) regulating senescence are not well characterized. Here, we find that ITGB3 (integrin beta 3 or β3) is epigenetically regulated by the Polycomb protein CBX7. β3 expr...
ORGANISM(S): Homo sapiens (Human) 
2017-03-09 | PXD005717 | Pride
Senescence Silac Cbx7 
ProteomicsCyclin-dependant kinase (CDK) orders the cell cycle via substrate specific thresholds
The appropriate ordering of the cell cycle events in eukaryoates is thought to be brought about by qualitative differences in the substrate specificity of multiple differentially expression Cyclin-CDK complexes. Our analysis of fission yeast supports an alternative quantitative model. Here we report...
ORGANISM(S): Schizosaccharomyces pombe 
2018-04-11 | PXD003598 | Pride
Mass spectrometry Cdk Silac Cell cycle S. pombe 
ProteomicsAnalysis of signaling endosome composition and dynamics using SILAC in embryonic stem cell-derived neurons
Neurons require efficient transport mechanisms such as fast axonal transport to ensure neuronal homeostasis and survival. Neurotrophins and their receptors are conveyed via fast axonal retrograde transport of signaling endosomes to the soma, where they elicit transcriptional responses. Despite the e...
ORGANISM(S): Mus musculus (Mouse) 
2015-12-21 | PXD002111 | Pride
Mass spectrometry Silac Motor neurons Signalling endosomes 
ProteomicsNucleocytoplasmic transport and membrane growth control nuclear size
How cells control the overall size of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size that is proportional to cellular size, resulting in a constant ratio between the nuclear and cellular volumes (N/C ratio). To shed light on...
ORGANISM(S): Schizosaccharomyces pombe 
2017-06-05 | PXD004530 | Pride
Nuclear cell ratio Nuclear size Silac 
ProteomicsCyclic AMP signalling controls key components of malaria parasite host cell invasion machinery
Cyclic nucleotides are important signalling molecules across evolution, but their roles in malaria parasites are poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional disruption of adenylyl cyclase (ACβ) and its downs...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2019-05-14 | PXD012143 | Pride
Host cell invasion Malaria Camp‐dependent protein kinase Adenylyl cyclase β Orbitrap fusion lumos Cyclic nucleotide signalling Ama1 Plasmodium falciparum 
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