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ProteomicsFunctional analysis of somatic variants found in endometrial tumor-specific ER-alpha enhancers
Biological implications of healthy- and tumor-specific ERα cistromes in endometrial tumors have largely been understudied. Moreover, the functional impact of non-coding somatic variants has commonly been underexplored and remained elusive. This study is aimed to provide functional interpretation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD029822 | Pride
Enhancers Endometrial cancer Er-alpha Somatic variants 
GenomicsMapping of somatic linker histone H1 variants in T47D-MTVL cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49334 | biostudies-arrayexpress
TranscriptomicsMapping of somatic linker histone H1 variants in T47D-MTVL and HeLa cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49333 | biostudies-arrayexpress
UnknownStandards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.
Not available
S-EPMC5707196 | biostudies-literature
GenomicsMacro histone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming
Transcription factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserve cell identity. In an effort to decipher the molecular natu...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-44400 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of human hepatocellular carcinoma
Deep high-throughput transcriptome sequencing (RNA-seq) performed on 3 pairs of matched tumor and adjacent non-tumorours (NT) tissues from HCC patients of Chinese origin generated 183.6-million reads that could be aligned. We discovered a number of differentially expressed genes and multiple types o...
ORGANISM(S): Homo sapiens 
2013-04-02 | E-GEOD-33294 | biostudies-arrayexpress
TranscriptomicsThe genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells
We employed the DamID technique to systematically map the genomic distribution of all canonical somatic H1 subtypes (H1.1-H1.5) in human IMR90 cells. Human cells contain up to eleven histone H1 proteins, with different spatial and temporal expression patterns. These include five canonical, replicati...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-40886 | biostudies-arrayexpress
GenomicsGBM Somatic variants
Genomic and mitochondrial DNA variants in (sequential) glioblastoma
PRJEB63610 | ENA
GenomicsAcquired somatic variants in inherited myeloid malignancies
Acquired somatic variants in inherited myeloid malignancies
PRJEB49554 | ENA
ProteomicsQuantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V
Lung cancer is the leading cause of cancer death both in men and women. Tumor heterogeneity is an impediment to targeted treatment of all cancers, including lung cancer. Here, we sought to characterize changes in tumor proteome and phosphoproteome by longitudinal, prospective collection of tumor tis...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010779 | Pride
Lung adenocarcinoma Proteomic heterogeneity Quantitative mass spectrometry 
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