Sort   by:  
 Page size 
TranscriptomicsSingle-cell RNA-seq of mouse cerebral cortex
We have applied a recently developed, highly accurate and sensitive single-cell RNA-seq method (STRT/C1) to perform a molecular census of two regions of the mouse cerebral cortex: the somatosensory cortex and hippocampus CA1. We isolated cells fresh from somatosensory cortex (S1) and hippocampus CA1...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-60361 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse primary somatosensory cortex (S1) in a neuropathic pain model after electroacupuncture stimulus
This study aims to identify the molecular mechanism in the sensory cortex underlying pain-relief effect of electroacupuncture
ORGANISM(S): Mus musculus 
2021-01-09 | E-MTAB-9987 | biostudies-arrayexpress
ProteomicsProteomic analysis of somatosensory cortex of Pten haploinsufficient mice
To discover differentially expressed proteins in somatosensory cortex of Pten haploinsufficient mice at adolescence (P30). Result reveals signatures of perturbation of dendritic spine development, keratinization and hamartoma. These are collectively respresentating molecular perturbation of neuropat...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-26 | PXD030573 | Pride
Q-exactive hf-x Pten Itraq Somatosensory cortex Lc-ms/ms 
ProteomicsProteomic landscape of the primary somatosensory cortex upon sensory deprivation
We employed label free quantitative mass spectrometry to address experience-dependent changes in the proteome after sensory deprivation in the primary somatosensory cortex. Cortical column- and layer-specific tissue samples were collected from control animals, with all whiskers intact, and animals w...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-24 | PXD005971 | Pride
Barrel cortex Juvenile mice Mass-spectrometry Whisker plucking Label-free quantification 
ProteomicsMulti-Omics Analysis Unveils Nsun5-Mediated Molecular Alterations in the Somatosensory Cortex and its Impact on Pain Sensation
Nsun5 assumes a pivotal role in the regulation of RNA methylation, and its deficiency has been linked to the advancement of hepatocellular carcinoma, gliomas, tetralogy of Fallot, cognitive deficits in Williams–Beuren syndrome (WBS), and brain development. This underscores Nsun5's significant involv...
ORGANISM(S): Mus Musculus 
2024-07-05 | PXD053689 |
TranscriptomicsTranscription profiling of different regions of E16.5 mouse cerebral cortex to identify region- and layer-specific genes.
The mammalian neocortex develops layer organizations with regional differences represented by expression of multiple genes at embryonic stages. These genes could play important roles in the formation of areal cyto-architecture, yet, the number of genes identified so far is not sufficient to explain ...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-929 | biostudies-arrayexpress
TranscriptomicsBulk RNASeq of mouse astrocytes isolated from the somatosensory cortex of control and Tcf7l2 conditional knockout (TdTomato+).
The aim of the experiment was to explain the role of astrocytic TCF7L2 transcription factor in astrocyte development and maturation. To do that we used Tcf7l2FL/FL:TdTomatoFL/FL animals with loxP sites that flanked exon 6, the deletion of which causes a frameshift mutation and leads to nonsense-medi...
ORGANISM(S): Mus musculus 
2024-06-28 | E-MTAB-13153 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus data for Uncovering the Molecular Logic of Cortical Wiring between Neuronal subtypes Across Development Through Ligand–Receptor Inference
The cerebral cortex comprises diverse excitatory and inhibitory neuron subtypes, each with distinct laminar positions and connectivity patterns. Yet, the molecular logic underlying their precise wiring remains poorly understood. To identify ligand–receptor (LR) interactions involved in cortical circ...
ORGANISM(S): Mus musculus 
2025-12-14 | E-MTAB-16355 | biostudies-arrayexpress
ProteomicsOptimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results
Comprehensive, reproducible and precise analysis of large sample cohorts is one of the key objectives of quantitative proteomics. Here, we present an implementation of data-independent acquisition using its parallel acquisition nature that surpasses the limitation of serial MS2 acquisition of data-d...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-01-30 | MSV000084874 | MassIVE
TranscriptomicsUncovering the Molecular Logic of Cortical Wiring between Neuronal subtypes Across Development Through Ligand–Receptor Inference
The cerebral cortex comprises diverse excitatory and inhibitory neuron subtypes, each with distinct laminar positions and connectivity patterns. Yet, the molecular logic underlying their precise wiring remains poorly understood. To identify ligand–receptor (LR) interactions involved in cortical circ...
ORGANISM(S): Mus musculus 
2026-01-30 | E-MTAB-16260 | biostudies-arrayexpress
Sort   by:  
 Page size