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We generated erlotinib-resistant HCC4006 cells (HCC4006ER) by chronic exposure of EGFR-mutant HCC4006 cells to increasing concentrations of erlotinib. HCC4006ER cells acquired an EMT phenotype and activation of the TGF-β/SMAD pathway, while lacking both T790M secondary EGFR mutation and MET gene amp...
ORGANISM(S): Homo sapiens 
Transcriptional responses of an unencapsulated Streptococcus pneumoniae strain derived from TIGR4 to human macrophages THP-1 were investigated at the early stages of interactions (0.5 h, 1 h and 3h).
ORGANISM(S): Streptococcus pneumoniae 
Transcriptional changes of an TCS08 mutant (disrupted in rr08) compared to the parent wild-type strain TIGR4 when both strains were cultured to early logarithmic growth phase in THY broth.
ORGANISM(S): Streptococcus pneumoniae 
We experimentally generated an ALK interactome combining quantitative tyrosine phosphoproteomics and protein complex annotation using affinity purification coupled with mass spectrometry and further investigated downstream ALK signaling using quantitative tyrosine phosphoproteomics.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004935 | Pride
Microarray Analysis of Human Whole Blood and Intestinal Biopsy Samples from a Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Crohn’s Disease 329 Crohn's biopsies from multiple regions in the intestine of 87 anti TNFa refractory patients an...
ORGANISM(S): Homo sapiens 
Transcriptional responses of Streptococcus pneumoniae strain TIGR4 to human lung epithelial cells (A549) were investigated at the early stages of interactions (0.5 h and 1 h).
ORGANISM(S): Streptococcus pneumoniae 
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