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ProteomicsSWATH mass spectrometry performance using extended ion assay libraries
The use of data-independent acquisition methods such as SWATH for mass spectrometry based proteomics is usually performed using peptide MS/MS reference ion assay libraries which enable identification and quantitation of peptide peak areas. Reference assay libraries can be generated locally through ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2016-05-12 | PXD002836 | Pride
Extended library Dia Swath 
ProteomicsAge-related cleavages of crystallins in human lens cortical fibre cells generate a plethora of endogenous peptides and high molecular weight complexes
Age-related breakdown of lenticular crystallins is associated with lenticular disorders such as cataract. Despite playing a critical role in maintaining lens homeostasis, the mechanism(s) and consequences of this phenomenon are not well understood. Utilising a proteomic-based approach, this study ch...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD001630 | Pride
Lens aging  crystallin  cataract  mass spectrometry  endogenous peptides  2-d gel electrophoresis  nanolc-esi-ms/ms  trypsin-like cleavage. 
ProteomicsAge-related cleavages of crystallins in human lens cortical fibre cells generate a plethora of low molecular weight peptides and cross-linked crystallin complexes
A large variety of low molecular weight (LMW) peptides, derived from the breakdown of crystallins, have been reported in middle to old age human lenses. The proliferation of these LMW peptides coincides with the earliest stages of cataract formation, suggesting that the protein cleavages involved ma...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD001593 | Pride
Human lens Crystallin Endogeneuous peptideslens aging  crystallin  cataract  mass spectrometry  endogenous peptides  2-d gel electrophoresis  nanolc-esi-ms/ms  trypsin-like cleavage 
ProteomicsQuantitative age-specific variability of plasma proteins in healthy neonates, children and adults
Human blood plasma is a complex biological fluid containing soluble proteins, sugars, hormones, electrolytes, and dissolved gasses. As plasma interacts with a wide array of bodily systems, changes in protein expression, or the presence or absence of specific proteins are regularly used in the clinic...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005661 | Pride
Adult and children plasma Human plasma Swath Age 
ProteomicsAge-related cleavages of crystallins in human lens cortical fibre cells generate a plethora of low molecular weight peptides and cross-linked crystallin complexes
A large variety of low molecular weight (LMW) peptides, derived from the breakdown of crystallins, have been reported in middle to old age human lenses. The proliferation of these LMW peptides coincides with the earliest stages of cataract formation, suggesting that the protein cleavages involved ma...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081536 | MassIVE
ProteomicsRespiratory complex II - Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD009656 | Pride
Mitochondria  sdha  energy utilization 
ProteomicsNafamostat Mesylate Augments Survival in Rats Afflicted by Exertional Heat Stroke
To evaluate the impact of Nafamostat mesylate (NM) in improving survival outcomes among rats subjected to exertional heat stroke.
ORGANISM(S): Mus Musculus 
PXD063689 |
ProteomicsHuman bladder cancer LC MS/MS
Urine is an ideal material to study and examine the bladder cancer (BCa) biomarkers, whereas exploration to the corresponding protein candidates is confronting technique challenges. Herein, we proposed a comprehensive strategy of searching the urine proteins related to BCa. The strategy consists of ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080696 | MassIVE
ProteomicsProteome and phosphoproteome landscape of silicosis occurrence in mice model
To map the multi-omics atlas of silicosis progression, we collected four replicates of whole lung lobes from mice at different stages (W2, W4, W6, W10) after silica-treated as well as W6 after PBS-treated (as control). Then we performed (phospho) proteome analysis as well as bioinformatic analysis.
ORGANISM(S): Mus Musculus 
2021-08-04 | PXD027693 |
UnknownEfficacy and Safety of Ginkgo Diterpene Lactone Meglumine in Acute Ischemic Stroke: A Randomized Clinical Trial.
Not available
S-EPMC10425831 | biostudies-literature
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