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ProteomicsEnforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration
Alteration to endoplasmic reticulum (ER) proteostasis is observed on a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteostasis and cell function. The UPR is initiated...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD022554 | Pride
Xbp1 Huntington`s disease Atf6 Upr Parkinson`s disease Er stress Protein aggregation 
UnknownEnforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.
Not available
S-EPMC8116614 | biostudies-literature
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
ProteomicsM.musculus - B cell, iBAQ (Gomez-cabreroetal,scidata2019)
abundance based on iBAQ, Interaction consistency score: 10.0, Coverage: 8
ORGANISM(S): 10090 
2019-00-00 | 3223737855 | PAXDB
ProteomicsM.musculus - B cell, iBAQ (Gomez-cabreroetal,scidata2019)
abundance based on iBAQ, Interaction consistency score: 11.5, Coverage: 8
ORGANISM(S): 10090 
2019-00-00 | 1257877986 | PAXDB
UnknownEvaluation of a combined strategy directed towards health-care professionals and patients with chronic obstructive pulmonary disease (COPD): information and health education feedback for improving clinical monitoring and quality-of-life.
Not available
S-EPMC2799410 | biostudies-literature
UnknownEffect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.
Not available
S-EPMC9073661 | biostudies-literature
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