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TranscriptomicsMechanism and transcriptional program of YB-1 in breast cancer cell lines.
YB-1 controls epithelial-mesenchymal transitions by restricting translation of growth-related mRNAs and enabling expression of EMT-inducing transcription factors. We used microarrays to characterize the direct transcriptional and indirect translational regulation of mRNAs by exogenous YB-1 in breast...
ORGANISM(S): Homo sapiens 
2008-10-30 | E-GEOD-13410 | biostudies-arrayexpress
ProteomicsSmall molecule inhibitors of eIF4A1/2 impair the oxidative stress response in osteosarcoma cells to block tumor growth and metastatic capacity
Effective therapies for metastatic osteosarcoma (OS) remain a major clinical unmet need. Targeting mRNA translation in metastatic OS represents an attractive option, as selective translation under stress supports the rapid synthesis of cytoprotective proteins that facilitate metastatic competence. W...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD047420 | Pride
Translation inhibitors Oxidative stress Rocaglates Osteosarcoma 
UnknownTumour blood flow for prediction of human prostate cancer aggressiveness: a study with Rubidium-82 PET, MRI and Na+/K+-ATPase-density.
Not available
S-EPMC7835182 | biostudies-literature
TranscriptomicsThe Hace1 E3 Ligase Modulates the Activity of Multiple Tumor Suppressive CRL E3 Ligases by binding to CAND1
The Hace1 E3 ligase is a tumor suppressor in stressed cells. Through unknown mechanisms, Hace1 indirectly targets the cyclin D1 proto-oncogene for proteasomal degradation during nutrient depletion. We now show that Hace1 targets HIF1alpha for VHL-dependent degradation during hypoxia. To better under...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-25452 | biostudies-arrayexpress
UnknownUrokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer.
Not available
S-EPMC5574145 | biostudies-literature
UnknownIntroduction and transmission of SARS-CoV-2 lineage B.1.1.7, Alpha variant, in Denmark.
Not available
S-EPMC9064402 | biostudies-literature
UnknownAndrogen Receptor (AR) antagonism triggers acute succinate-mediated adaptive responses to reactivate AR signaling
Not available
S-SCDT-EMM-2020-13427 | biostudies-other
TranscriptomicsTranscription profiling of mammary tissues from mouse model of breast cancer conditionally expressing Etv6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation
For the largest class of human tumors, those of epithelial origin, little is known about their initiating genetic hits or cells of origin. Whether tissue stem cells or more committed progenitors are targets for transformation is also uncertain. Experience in hematopoietic malignancies and sarcomas ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9343 | biostudies-arrayexpress
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