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ProteomicsTotal protein profiles of human induced pluripotent stem cell-derived cardiomyocytes in response to four tyrosine kinase inhibitors
Drug-induced cardiotoxicity is a widespread clinical issue affecting numerous drug classes and remains difficult to treat. One such drug class is Tyrosine Kinase Inhibitors (TKIs), which cause varying degrees of contraction-related cardiotoxicity usually after weeks of exposure. Understanding molecu...
ORGANISM(S): Homo sapiens (Human) 
2019-05-16 | PXD012043 | Pride
Tyrosine kinase inhibitor Cardiotoxicity Aerobic glycolysis Human induced pluripotent stem cell-derived cardiomyocyte Mitochondrial respiration Drug adaptation Tandem mass tag mass spectrometry 
ProteomicsA dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line
The immortalized human ReNcell VM cell line represents a reproducible and easy-to-propagate cell culture system for studying the differentiation of neural progenitors. To better characterize the starting line and its differentiation, we assessed protein and phospho-protein levels over a two-week per...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010846 | Pride
Differentiation Phosphoproteomics Neuron Tmt Orbitrap fusion lumos Lc-ms/ms 
ModelsAlbeck2008_extrinsic_apoptosis
This the model used in the article: Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. Mol Cell. 2008 Apr 11;30(1):11-25. PMID...
2024-09-02 | BIOMD0000000220 | BioModels
ModelsEGFR & ErbB Signaling
The epidermal growth factor receptor (EGFR) signaling pathway is probably the best-studied receptor system in mammalian cells, and it also has become a popular example for employing mathematical modeling to cellular signaling networks. Dynamic models have the highest explanatory and predictive poten...
2309 | Cell Collective
UnknownAntigen reactivity defines tissue-resident memory and exhausted T cells in tumors.
Not available
S-EPMC12764432 | biostudies-literature
UnknownHighly multiplexed imaging by Cyclic Immunofluorescence (CycIF) of protein levels and protein phosphorylation states in the COLO 858 melanoma cell line
Not available
2015-11-25 | LDS-1242 | LINCS
UnknownMetrics other than potency reveal systematic variation in responses to cancer drugs
Not available
2016-05-06 | LDS-1106 | LINCS
UnknownBreast cell line dose response to target inhibition measured by high throughput microscopy
Not available
2016-05-09 | LDS-1122 | LINCS
Unknown,MultiomicsPLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines
Not available
2015-09-23 | LDS-1219 | LINCS
Unknown,MultiomicsViability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging
Not available
2015-09-23 | LDS-1208 | LINCS
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