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ProteomicsSorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated pathologies we performed proteomics in rat primary neurons to ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-28 | PXD026289 | Pride
Membrane trafficking Snx27 Lrfn2 Ampa receptors 
GenomicsSorting nexin 10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting
Sorting nexin 10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting
PRJNA915602 | ENA
GenomicsThe Role of Sorting Nexin 17 in Cardiac Development
The Role of Sorting Nexin 17 in Cardiac Development
PRJNA775617 | ENA
ProteomicsPhosphorylation of SNX17 impedes activation of Retriever-mediated sorting
Sorting nexin 17 (SNX17) functions as cargo receptor on endosomal membranes that enables the recycling of numerous membrane cargo proteins by binding to the Retriever complex. Yet, little is known how SNX17 activity or its membrane recruitment is regulated. Here, we report that phosphorylation of SN...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-30 | PXD061808 | Pride
Endosome Intracellular trafficking Sorting nexin Retriever Phosphorylation Integrin Phox domain 
ProteomicsProteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins
The sorting nexin SNX17 controls endosome-to-cell surface recycling of diverse transmembrane cargo proteins including integrins, the amyloid precursor protein and lipoprotein receptors. This requires association with the multi-subunit Commander trafficking complex, which depends on the C-terminus of...
ORGANISM(S): Homo sapiens (Human) 
2022-11-07 | PXD036424 | Pride
Endosome Pdz domain Snx17 Commander Retriever Pdlim 
TranscriptomicsSorting nexin 10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting
Glioblastoma is the most malignant primary brain tumor for which the prognosis is still dismal despite aggressive surgical, medical, and radiation therapies. Glioblastoma stem cells (GSCs) promote therapeutic resistance and cellular heterogeneity due to their self-renewal properties and capacity for...
ORGANISM(S): Homo sapiens 
2023-03-31 | GSE221714 | GEO
UnknownSorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin.
Not available
S-EPMC6140323 | biostudies-literature
UnknownSLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.
Not available
S-EPMC3414251 | biostudies-literature
UnknownSorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs.
Not available
S-EPMC4136608 | biostudies-literature
UnknownThe Role of Sorting Nexin 17 in Cardiac Development.
Not available
S-EPMC8720881 | biostudies-literature
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