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TranscriptomicsThe evolution of lncRNA repertoires and expression patterns in tetrapods
Only a minuscule fraction of long non-coding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but comparative analyses have been precluded by our ignorance of lncRNAs in non-model organisms. Here, we use RNA sequencing to ident...
ORGANISM(S): Ornithorhynchus anatinus 
2014-01-19 | E-GEOD-43520 | biostudies-arrayexpress
TranscriptomicsPlatypus fibroblast and ovary transcriptomes
As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore dosage balance between the X and autosomes, and that the resulting X ...
ORGANISM(S): Ornithorhynchus anatinus 
2012-05-16 | E-GEOD-36120 | biostudies-arrayexpress
TranscriptomicsEvolution of mammalian miRNA genes
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their origins and functional evolution in mammals remain little understood due to the lack of appropriate comparative data. Using RNA sequencing, we have generated extensive and comparable miRNA data for five organs...
ORGANISM(S): Macaca mulatta 
2012-10-01 | E-GEOD-40499 | biostudies-arrayexpress
TranscriptomicsCellular source and mechanisms of high transcriptome complexity in the mammalian testis (RNA-Seq organs)
Understanding  the  extent  of  genomic  transcription  and  its  functional  relevance  is  a  central  goal  in  genomics research. However, detailed genome‐wide investigations of transcriptome complexities in major mammalian organs  and  their  underlying  cellular  sources,  transcriptional  mec...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43721 | biostudies-arrayexpress
TranscriptomicsCellular source and mechanisms of high transcriptome complexity in the mammalian testis (RNA-Seq cells)
Understanding the extent of genomic transcription and its functional relevance is a central goal in genomics research. However, detailed genome€wide investigations of transcriptome complexities in major mammalian organs  and  their  underlying  cellular sources, transcriptional mechanisms, and func...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43717 | biostudies-arrayexpress
TranscriptomicsCharacterization of differentiating adipose cells by high-throughput single-cell RNA-Seq
Directed differentiation of cells in vitro is a powerful approach for dissection of developmental pathways, disease modeling and regenerative medicine, but analysis of such systems are complicated by heterogeneous and asynchronous cellular responses to differentiation-inducing stimuli. To enable dee...
ORGANISM(S): Homo sapiens 
2014-12-23 | E-GEOD-53638 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 6 tissues from Monodelphis domestica to investigate the evolution of gene expression levels in mammalian organs
This experiment contains the subset of data corresponding to gray short-tailed opossum RNA-Seq data from experiment E-GEOD-30352 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30352/), which goal is to understand the dynamics of mammalian transcriptome evolution. To study mammalian transcript...
ORGANISM(S): Monodelphis domestica 
2011-10-12 | E-MTAB-3719 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 6 tissues from Homo sapiens to investigate the evolution of gene expression levels in mammalian organs
This experiment contains the subset of data corresponding to human RNA-Seq data from experiment E-GEOD-30352 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30352/), which goal is to understand the dynamics of mammalian transcriptome evolution. To study mammalian transcriptome evolution at hig...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-MTAB-3716 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 6 tissues from Macaca mulatta to investigate the evolution of gene expression levels in mammalian organs
This experiment contains the subset of data corresponding to rhesus macaque RNA-Seq data from experiment E-GEOD-30352 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30352/), which goal is to understand the dynamics of mammalian transcriptome evolution. To study mammalian transcriptome evoluti...
ORGANISM(S): Macaca mulatta 
2011-10-12 | E-MTAB-3717 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 6 tissues from Mus musculus to investigate the evolution of gene expression levels in mammalian organs
This experiment contains the subset of data corresponding to mouse RNA-Seq data from experiment E-GEOD-30352 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30352/), which goal is to understand the dynamics of mammalian transcriptome evolution. To study mammalian transcriptome evolution at hig...
ORGANISM(S): Mus musculus 
2011-10-12 | E-MTAB-3718 | biostudies-arrayexpress
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