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ProteomicsFrontiers in Plasma Proteome Profiling Platforms: Innovations and Applications.
Biomarkers play a crucial role in advancing precision medicine by enabling more targeted and individualized approaches to diagnosis and treatment. Various biofluids, including serum, plasma, cerebrospinal fluid (CSF), saliva, tears, pancreatic cyst fluids, and urine, have been identified as rich sou...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050425 | Pride
Biomarker Sp100 instrument Biofluids proteome profiling Preomics-ist Seer proteograph Timstofpro2 Secretome Plasma proteome 
ProteomicsAffinity Purification experiments for 24 human Bromodomain proteins involved in DNA repair and genome integrity (part 1 of 2).
Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability, as well as therapeutic targets in cancer. In our associated publication (doi:10.1101/gad.331231.119) we systematically delineate the contribution of human BRD proteins for genome stability and DNA double-strand...
ORGANISM(S): Homo sapiens (Human) 
2019-12-12 | PXD016700 | Pride
R-loops Dna repair Human Bromodomain Chromatin Ap-ms Dna damage response Homologous recombination 
ProteomicsNanoparticle Enrichment Mass-Spectrometry Proteomics Identifies Protein Altering Variants for Precise pQTL Mapping
Proteogenomics studies generate hypotheses on protein function and provide genetic evidence for drug target prioritization. Most previous work has been conducted using affinity-based proteomics approaches. These technological face challenges, such as uncertainty regarding target identity, non-specif...
ORGANISM(S): Homo sapiens (Human) 
2023-12-19 | PXD042852 | Pride
Protein altering variants Proteomics Protein quantitative trait loci Mass spectrometry Genome-wide association studies Proteograph™ workflow 
ProteomicsAffinity Purification experiments for 24 human Bromodomain proteins involved in DNA repair and genome integrity (part 2 of 2)
Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability, as well as therapeutic targets in cancer. In our associated publication (doi:10.1101/gad.331231.119) we systematically delineate the contribution of human BRD proteins for genome stability and DNA double-strand...
ORGANISM(S): Homo sapiens (Human) 
2019-12-12 | PXD016673 | Pride
R-loops Dna repair Human Bromodomain Chromatin Ap-ms Dna damage response Homologous recombination 
ProteomicsIdentification of Putative Kidney-Derived Proteins in Plasma using Nanoparticle Enrichment
Many diseases, including diabetes and hypertension, can lead to kidney damage, often resulting in long-term health complications and organ failure. Both animal and human studies have documented a causal relationship between high dietary sodium intake and elevated blood pressure. We explored a proteo...
ORGANISM(S): Papio hamadryas 
2026-03-30 | PXD071248 | Pride
Lc-msms Plasma Tissue-leakage proteins Diet challenge Kidney Baboon Non-human primates Sodium Nanoparticle affinity enrichment 
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