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MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_MALDI imaging]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12601 | MetaboLights
MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
TranscriptomicsGBM-Space: Spatial Transcriptomic Profiling of Glioblastoma (10x Genomics - Visium)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17164 | biostudies-arrayexpress
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_LCM]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12561 | MetaboLights
TranscriptomicsTranscription profiling of hippocampi from scopolamine treated adult rats following stimulation in a spatial memory task
Hippocampal gene expression profiling in scopolamine treated adult rats following stimulation in a spatial memory task
ORGANISM(S): Rattus norvegicus 
2006-12-30 | E-MEXP-920 | biostudies-arrayexpress
ProteomicsSpatial differentiation of gene expression in Aspergillus niger colony grown for sugar beet pulp utilization
Degradation of plant biomass to fermentable sugars is of critical importance for the use of plant materials for biofuels. Filamentous fungi are ubiquitous organisms and major plant biomass degraders. Single colonies of some fungal species can colonize massive areas as large as five soccer stadia.Dur...
ORGANISM(S): Aspergillus niger 
2015-09-09 | PXD002130 | Pride
Heterogeneity  sugar beet pulp Aspergillus niger Spatial gene expression Plant biomass degrading enzymes 
Transcriptomics14 primary formalin fixated paraffin embedded (FFPE) PDAC tissue slices from 14 patients without pretreatment were analyzed using spatial transcriptomics
Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular heterogeneity and poor prognosis, necessitating novel tailored therapies. The basal and classical molecular subtypes of PDAC - driven by glycolysis versus lipid metabolism - have distinct prognostic implications. Spatial transcripto...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-15702 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics of human heart development
This experiment uses 10x Genomics Visium HD spatial transcriptomics to characterise the cellular and molecular organisation of the developing human heart.
ORGANISM(S): Homo sapiens 
2026-09-23 | E-MTAB-17440 | biostudies-arrayexpress
Transcriptomicsspatial transcriptomics (10x Visium) of first and second trimester human reproductive tract
spatial transcriptomics by means of 10x Visium of first and second trimester human reproductive tract (including female and male internal and external genitalia)
ORGANISM(S): Homo sapiens 
2025-08-06 | E-MTAB-15471 | biostudies-arrayexpress
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