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MetabolomicsSpatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

Spatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

2025-11-26 | MTBLS12782 | MetaboLights
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_MALDI imaging]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12601 | MetaboLights
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_LCM]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12561 | MetaboLights
MetabolomicsSingle-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance
Multi-drug resistance (MDR) is an almost inevitable end point of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cel...
2027-08-13 | MTBLS15322 | MetaboLights
MetabolomicsSpatial and Untargeted Metabolomics Define Location- and Histology-Specific Metabolic Reprogramming in Colorectal Cancer

Colorectal cancer (CRC) exhibits profound molecular heterogeneity based on primary tumor location. A comprehensive understanding of the spatially resolved metabolic differences between right-sided (RCC) and left-sided (LCC) carcinomas remains elusive. Here, to eliminate the influence of inter-ind...

2026-03-24 | MTBLS13729 | MetaboLights
TranscriptomicsA spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche - Visium
Multiple distinct cell types of the human lung and airways have been defined by single cell RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define novel cell types which we map back into the macro- and micro-anatomical tissue context to define functional tissue microen...
ORGANISM(S): Homo sapiens 
2022-01-06 | E-MTAB-11640 | biostudies-arrayexpress
TranscriptomicsGBM-Space: Spatial Transcriptomic Profiling of Glioblastoma (10x Genomics - Visium)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17164 | biostudies-arrayexpress
ProteomicsMS imaging-guided microproteomics for spatial omics on a single instrument
Mass spectrometry imaging (MSI) allows investigating the spatial distribution of chemical compounds directly in biological tissues. As the analytical depth of MSI is limited, MSI needs to be coupled to more sensitive local extraction-based omics approaches to achieve a comprehensive molecular charac...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD020362 | Pride
Spatial omics Microproteomics Laser microdissection Mass spectrometry imaging 
GenomicsDeciphering spatial domains from spatial multi-omics with SpatialGlue
Deciphering spatial domains from spatial multi-omics with SpatialGlue
PRJNA1098416 | ENA
ProteomicsMALDI-MSI-guided LCM-MS: Advancing spatial multi-omics in mouse brain tissue
Spatial multi-omics involves the analysis of biomolecules such as proteome, metabolome, and lipidome within their native spatial context in tissues or cells. This approach provides a comprehensive understanding of biomolecular networks in specific biological environments. Mass spectrometry imaging (...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD060073 | Pride
Lcm-ms Spatial omics Maldi-msi 
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