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TranscriptomicsExpression data from RDI treated T-ALL cells
RUNX1 and CBFB, which encode subunits of the core binding factor, are frequent targets of chromosomal aberrations in hematological malignancies. We previously determined that CBFβ (encoded by CBFB) is important for the transforming activity of the chimeric protein AML1-ETO (RUNX1-RUNX1T1) generated...
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-70495 | biostudies-arrayexpress
GenomicsDNA specificity determinants associate with distinct transcription factor functions
To elucidate how genomic sequences build transcriptional control networks we need to understand the connection between DNA sequence and transcription factor binding and function. Binding predictions based solely on consensus predictions are limited because a single factor can use degenerate sequenc...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-17954 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of antigen-specific T cells upon CCR9 knockdown in MCF7 cells.
Tumor cells are known to express immune-inhibitory ligands on their surface to mediate resistance against cytotoxic T lymphocytes. Using a high-throughput RNAi screening assay, we identified CCR9 as a potent tumor-specific immune checkpoint molecule that inhibited T cell-mediated tumor lysis. To und...
ORGANISM(S): Homo sapiens 
2015-02-19 | E-MTAB-3244 | biostudies-arrayexpress
UnknownThe ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct.
Not available
S-EPMC8566762 | biostudies-literature
ProteomicsAIM2 in regulatory T (Treg) cells restrains autoimmune diseases
The inflammasome initiates innate defense and inflammatory response by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It is comprised of an innate immune receptor/effector, pro-caspase-1 and a common adaptor molecule, ASC (apoptotic speck-containing protein with a CARD). Consis...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD018638 | Pride
Autoimmunity Aim2 (absent in melanoma 2) Akt-mtor signaling 
UnknownAn optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection.
Not available
S-EPMC546552 | biostudies-literature
UnknownA gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.
Not available
S-EPMC2275388 | biostudies-literature
UnknownRapamycin ameliorates the CTLA4-Ig-mediated defect in CD8(+) T cell immunity during gammaherpesvirus infection.
Not available
S-EPMC5389899 | biostudies-literature
UnknownA high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytes.
Not available
S-EPMC4403046 | biostudies-literature
UnknownThe Inflammasome Adaptor ASC Intrinsically Limits CD4+ T-Cell Proliferation to Help Maintain Intestinal Homeostasis.
Not available
S-EPMC6644529 | biostudies-literature
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