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ProteomicsCaMKII phosphorylates βIV-spectrin in heart
Fibrosis is a pronounced feature of heart disease and the result of dysregulated activation of resident cardiac fibroblasts (CFs). Recent work identified stress-induced degradation of the cytoskeletal protein βIV-spectrin as an important step in CF activation and cardiac fibrosis. Further, loss of β...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Chlorocebus sabaeus 
2022-02-17 | PXD025776 | Pride
Cardiac fibroblast Fibrosis Calmodulin kinase ii Stat3 Βiv-spectrin 
ProteomicsβIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus highlighting the need for greater understanding of the vast crosstalk and compensatory mechanisms. Based on proteomic profiling of angiogenic endotheli...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-04 | PXD026618 | Pride
Sprouting angiogenesis  vegf signaling  tip-stalk cell specification  spectrins 
GenomicsβIV-spectrin/STAT3 complex regulates the orientation of hypertrophic growth
βIV-spectrin/STAT3 complex regulates the orientation of hypertrophic growth
PRJNA1291125 | ENA
ProteomicsStructural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration
Axon degeneration sculpts precise patterns of connectivity in the developing nervous system and is an early pathological hallmark of several adult-onset neurodegenerative disorders. Substantial progress has been made in identifying effector mechanisms that drive axon fragmentation, but far less is k...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-14 | PXD009854 | Pride
Proteomics Axon degeneration Phosphorylation 
ProteomicsProteomic and functional analyses of the periodic membrane skeleton in neurons
Actin, spectrin, and associated proteins form a membrane-associated periodic skeleton (MPS) in neurons. The molecular composition and functions of the MPS remain incompletely understood. Here, we combined co-immunoprecipitation and mass spectrometry analyses to identify candidate MPS-interacting pro...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-04 | PXD030886 | Pride
Neuron Proteomics Actin Membrane skeleton Spectrin 
TranscriptomicsGene expression analysis of wild-type and Beta-2-spectrin homozygous knockout (β2SP-/-) mouse embryonic fibroblasts
Gene expression profiling was carried out in wild and β2SP-/- (Sptbn1 -/-) mouse embryonic fibroblast (MEF) cells. Beta-2-spectrin (β2SP) is a dynamic intracellular non-pleckstrin homology (PH)-domain protein that belongs to a family of polypeptides that have been implicated in conferring cell pol...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-65987 | biostudies-arrayexpress
ProteomicsSpectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from 1-3, and subunits. Here, we isolate distinct GABAARs from the brain and interrogate their composition using quantitative pr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD038703 | Pride
Ais Gaba a receptors Spectrins 
GenomicsCardiomyocyte βII Spectrin Plays a Critical Role in Maintaining Cardiac Function via Regulating Mitochondrial Respiratory Function
Cardiomyocyte βII Spectrin Plays a Critical Role in Maintaining Cardiac Function via Regulating Mitochondrial Respiratory Function
PRJNA950076 | ENA
TranscriptomicsβIV-spectrin/STAT3 complex regulates the orientation of hypertrophic growth
Background: Cardiac hypertrophy, defined as a stress-induced increase in heart mass/size, is a major risk factor for adverse cardiovascular events including heart failure and arrhythmia. Within this general definition, the orientation of cell and organ growth varies considerably depending on stress ...
ORGANISM(S): Mus musculus 
2025-10-08 | GSE302522 | GEO
UnknownSpectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway.
Not available
S-EPMC2064573 | biostudies-literature
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