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MetabolomicsMetagenomic and Metabolomic Analysis of Gut Microbiota's Impact on Sperm Motility in Rongchang Boars


This study focused on the association between gut microbiota and sperm motility, with an emphasis on analyzing differential metabolites in the intestines and blood of Rongchang boars from the high sperm motility group (group H) and low sperm motility group (group L). The results reveal...

2025-07-14 | MTBLS12712 | MetaboLights
MetabolomicsSericin Enhances Cryopreserved Sperm Quality in Chengde Hornless Black Goats by increasing Glutamine metabolism

Cryopreservation of Chengde polled goat semen plays a critical role in conserving genetic resources, enhancing the utilization efficiency of superior breeding rams, and advancing artificial insemination techniques. However, spermatozoa are vulnerable to oxidative stress during the freezing proces...

2025-08-15 | MTBLS12860 | MetaboLights
MetabolomicsIntegrative analysis of blood biochemistry and sperm metabolome profiles reveals metabolic determinants of cryotolerance in Bali bulls under standardized nutritional conditions

Enhancing the nation's beef supply and guaranteeing long-term food security requires increasing the effectiveness of artificial insemination (AI) in Bali cattle (Bos javanicus). Cryotolerance, or post-thaw variability in semen quality, limits AI results and probably reflects systemic and cellular...

2026-01-20 | MTBLS13639 | MetaboLights
MetabolomicsTEX44 CPT1B Axis Regulates Mitochondrial Sheath Assembly and Fatty Acid Oxidation in Sperm
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its specific role in sperm function has remained unclear. Through whole-exome sequencing of 673 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all ...
2025-07-14 | MTBLS12397 | MetaboLights
MetabolomicsTEX44 CPT1B Axis Regulates Mitochondrial Sheath Assembly and Fatty Acid Oxidation in Sperm

Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its specific role in sperm function has remained unclear. Through whole-exome sequencing of 673800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals...

2025-07-14 | MTBLS12402 | MetaboLights
MetabolomicsNGT induced mitochondrial dysfunction, led to apoptosis, and changed metabolites associated with oxidized lipids in sperm of Pacific oyster (Crassostrea gigas).

The risk of norgestrel (NGT) exposure in the aquatic environment has been identified, but the toxic effects on invertebrate germ cells are unknown. Therefore, the toxic effects of NGT on oyster sperm were investigated by combining transcriptome and metabolome analysis with histology. Transcriptom...

2025-07-05 | MTBLS12685 | MetaboLights
TranscriptomicsStallion sperm transcriptome as revealed by microarray analysis and RNA sequencing
Purpose: In order to understand the functional significance of sperm transcriptome in stallion fertility, the aim of this study was to generate a detailed body of knowledge about the sperm RNA profile that defines a normal fertile stallion. Methods: The 50 bp single-end ABI SOLiD raw reads were dire...
ORGANISM(S): Equus caballus 
2013-02-19 | E-GEOD-38725 | biostudies-arrayexpress
ProteomicsComparative proteomic and phosphorylated proteomic analyses revealed differences in sperm motility in Mediterranean buffalo
In this study, Mediterranean buffalo semen was used as experimental material, and quantitative proteomics and phosphorylation modification techniques were used to analyze the proteins and phosphorylation sites of Mediterranean buffalo sperm with different motility, so as to further study the protein...
ORGANISM(S): Bos Taurus 
PXD055618 |
TranscriptomicsDifferential RNAs in the sperm cells of asthenozoospermic patients
Alterations in the presence of sperm RNAs have been identified using microarrays in teratozoospermic (abnormal morphology) or other types of infertile patients. However, so far no studies had been reported on the sperm RNA content using microarrays in asthenozoospermic patients (low motility). We st...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-34514 | biostudies-arrayexpress
TranscriptomicsmRNA Content of Human Sperm
BACKGROUND: In previous studies using candidate gene approaches, low sperm count (oligospermia) has been associated with altered sperm mRNA content and DNA methylation in both imprinted and non-imprinted genes. We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-26881 | biostudies-arrayexpress
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