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MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
TranscriptomicsExpression data from aged spermatogonial stem cells
In vitro and in vivo aging of mouse spermatogonial stem cells alters stem cell function based on quantitative spermatogonial stem cell transplantation analyses. We used microarrays to identify differential gene expression in vitro and in vivo aged spermatogonial stem cells to identify potential caus...
ORGANISM(S): Mus musculus 
2011-02-04 | E-GEOD-27043 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spermatogonial stem cells established from 6 day old male mice to identify GDNF regulated genes by comparing cells in the presence, absence and timed replacement of GDNF
GDNF-regulated gene expression was studied in cultures of actively self-renewing spermatogonial stem cells established from 6 day old male mice. GDNF is the essential growth factor regulating mouse spermatogonial stem cell self-renewal. Using a serum-free chemically defined culture system that suppo...
ORGANISM(S): Mus musculus 
2007-11-24 | E-GEOD-4799 | biostudies-arrayexpress
TranscriptomicsDNMT3L promotes quiescence in postnatal spermatogonial progenitor cells
We analyzed transcriptome profiles of postnatal germ cells and demonstrated that DNMT3L is important for spermatogonial stem/progenitor cell development Examination of wild-type and Dnmt3l knockout smaples in postnatal male germ cells
ORGANISM(S): Mus musculus 
2014-07-03 | E-GEOD-54411 | biostudies-arrayexpress
TranscriptomicsSequencing of microRNA in spermatogonial stem cell enriched cell populations.
MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems where their functions include the regulation of self-renewal, cellular differentiation, proliferation, and apoptosis. However, the functional importance of individual miRs in controlling spermatogoni...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-29613 | biostudies-arrayexpress
ProteomicsA regulatory role for CHD4 in maintenance of the spermatogonial stem cell pool
Maintenance and self-renewal of the spermatogonial stem cell (SSC) population is the cornerstone of male fertility. In this manuscript we have identified a key role for the nucleosome remodelling protein Chromodomain Helicase DNA binding protein 4 (CHD4) in regulating SSC function. Gene expression a...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-17 | PXD022066 | Pride
Spermatogonial stem cell Chd4 Mi-2β Self-renewal 
TranscriptomicsTranscription profiling of mouse model or ERM deficiency - analysis of germ stem cell loss
ERM knockout mice were produced. Testis develop a Sertoli cell only; syndrome, which appears complete by 10 weeks of age in male ERM knockout mice. Three sets of Affymetrix comparisons were made. #1 and #2, Wt or ERM knockout testis from 4 week old males, totaly RNA. This time preceeds any signifi...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-2205 | biostudies-arrayexpress
ProteomicsProteomic profiling of RNA binding proteins in mouse spermatogonial stem cell
RNA-binding proteins (RBPs) control the fate of RNAs. Tissue regeneration and homeostasis depend on tissue-specific stem cells, but the scope of RBP involvementin these processes remains largely unknown. Here, we identified the RBP repertoire of the mouse undifferentiated spermatogonial population t...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-19 | PXD017377 | Pride
Mouse Shotgun proteomics Mrna interactome capture Rna-binding proteins Spermatogonial stem cell 
UnknownFunctionally redundant roles of ID family proteins in spermatogonial stem cells.
Not available
S-EPMC11561458 | biostudies-literature
ProteomicsEGR4-dependent decrease of UTF1 is associated with failure to reserve spermatogonial stem cells in infertile men
Despite the high incidence of male infertility, about 70% of infertile men do not receive a causative diagnosis. To gain insights into the regulatory mechanisms governing human germ cell function in normal and impaired spermatogenesis (crypto group), we combined single cell RNA sequencing (>30.000 c...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD023979 | Pride
Male germline stem cells Spermatogonial stem cells Testis Proteomics Impaired spermatogenesis Single cell rna sequencing Mass spectrometry Stem cell differentiation Male infertility Human spermatogenesis 
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