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MetabolomicsSphingosine-1-phosphate receptor 1 promotes ovarian cancer tumorsphere proliferation and metastasis
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites at diagnosis, a poor prognostic indicator. Malignant ascites ...
2026-03-04 | MTBLS13770 | MetaboLights
TranscriptomicsSphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells
Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimu...
ORGANISM(S): Homo sapiens 
2015-06-18 | E-GEOD-58657 | biostudies-arrayexpress
ProteomicsProteomics of murine melanoma tumor cells upon sphingosine kinase-1 inhibition
In order to assess the impact of sphingosine kinase-1 (SK1) expression on melanoma growth, stable SK1 knockdown cells were generated by shRNA, using Yumm 1.7 cells derived from spontaneous murine melanoma driven by Braf activation as well as Pten and Cdkn2a inactivation. Two cell lines silenced for ...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-17 | PXD016535 | Pride
Sphingosine kinase-1 Shotgun proteomics Murine cell line Melanoma 
TranscriptomicsTranscription profiling of human male embryonic stem cell line line grown in standard conditions, with feeder cells and treated with the signalling sphingolipid sphingosine-1-phosphate reveals S1P mediates key targets associated with survival, proliferation and pluripotency
Human embryonic stem cells (hESCs) replicate by the process of self-renewal, whilst maintaining their pluripotency. Understanding the pathways involved in the regulation of this self-renewal process will assist in developing fully-defined conditions for the proliferation of hESCS required for the...
ORGANISM(S): Homo sapiens 
2009-04-30 | E-GEOD-7896 | biostudies-arrayexpress
GenomicsSphingosine kinase 1 regulates the pulmonary vascular immune response
Sphingosine kinase 1 regulates the pulmonary vascular immune response
PRJNA729260 | ENA
TranscriptomicsSphingosine survival response of Staphylococcus aureus and Staphylococcus epidermidis
S. aureus and S. epidermidis were challenged with D-sphingosine, an antimicrobial lipid similar to sphingosines found in the major staphylococcal niche- human skin. Comparison of responses was used to identify resistance mechanisms and likely mode of action
ORGANISM(S): Staphylococcus aureus 
2020-10-01 | E-MTAB-9272 | biostudies-arrayexpress
TranscriptomicsImpact of Sphingosine Kinase-1 knock out in neonatal mice lungs
Sphingosine Kinase-1 knock out protects against hyperoxic lung injury One day old Wild type (WT) control and Sphingosine Kinase-1 knock out (SphK-1 KO)pups exposed to room air (RA) or hyperoxia (HO). Microarray based profiling of lung tissue after 7 days of hyperoxia of 75%
ORGANISM(S): Mus musculus 
2016-10-30 | GSE87350 | GEO
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
UnknownResveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival.
Not available
S-EPMC3419905 | biostudies-literature
TranscriptomicsSphingosine kinase 1 regulates the pulmonary vascular immune response
Aberrant proliferation of pulmonary arterial smooth muscle (PASMCs) cells are a defining characteristic of pulmonary arterial hypertension (PAH) and leads to increased vascular resistance, elevated pulmonary pressure, and right heart failure. The Sphingosine kinase 1 (SPHK1)/Sphingosine-1 phosphate/...
ORGANISM(S): Homo sapiens 
2021-06-22 | GSE174304 | GEO
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