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TranscriptomicsTranscription profiling of rat spinal cord with experimental autoimmune encephalomyelitis at 3 disease points, acute, relapsing and recovering vs. controls
The intention of the study was to examine the spinal cord gene expression at three different EAE disease points and to compare them with three nonimmunised, healthy rats. We immunised female DA rats with recombinant MOG-protein and sacrificed them during the acute phase of EAE defined as the first E...
ORGANISM(S): Rattus norvegicus 
2007-05-15 | E-MEXP-1025 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis grown at reduced oxygen tension to identify regulators of the hypoxic response
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-312 | biostudies-arrayexpress
ProteomicsProteomic analysis reveals critical immunomolecular mechanisms in macrophage anti-tuberculosis processes
Tuberculosis infection activates the autoimmune system. However, the role of autoimmunity after Mycobacterium tuberculosis infection is unclear. In this study, liquid chromatography-tandem mass spectrometry (LC-MS/MS) combined with tandem mass spectrometry (TMT) was used to perform proteomic analysi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD022541 | Pride
Spinal tuberculosis Proteomics Immunology Macrophages Bioinformatics 
GenomicsMycobacterium tuberculosis
Genomic insights into Mycobacterium tuberculosis for understanding the mechanisms of spinal tuberculosis
PRJNA1091826 | ENA
TranscriptomicsEndogenous IFN-I induced gene expression alterations in splenic T cells and spinal cord during priming phase of experimental autoimmune encephalomyelitis (EAE)
Assessment of whether endogenous IFN-I exerts genome-wide gene expression changes in splenic CD3 T cells and spinal cord during priming phase of EAE, we performed transcriptome analysis on T cells and spinal cord derived from 3-month old IFNAR1Texcl and WT animals on day 10 upon EAE induction.
ORGANISM(S): Mus musculus 
2015-04-02 | E-MTAB-2989 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR knockout screen in Mycobacterium tuberculosis infected macrophages to identify regulators of TNF and iNOS expression
To elucidate the early regulators of inflammation during Mycobacterium tuberculosis infection, we performed a genome-wide CRISPR knockout screen in macrophages to identify genes that influence the induction of TNF and iNOS upon infection. A genome-wide knockout library in murine macrophages was infe...
ORGANISM(S): Mus musculus 
2026-04-29 | E-MTAB-15739 | biostudies-arrayexpress
TranscriptomicsGene expression data from spinal cord of DRa1-mMOG-35-55 or Vehicle treated DR*1501-Tg mice with EAE
To evaluate DR?1-mMOG-35-55 effects on CNS inflammation during Experimental allergic encephalomyelitis (EAE) in a more comprehensive manner, we performed microarray analysis on spinal cords from DR?1-mMOG-35-55- vs. Vehicle-treated DR*1501-Tg mice with EAE. EAE was induced with mMOG-35-55/CFA/Ptx a...
ORGANISM(S): Mus musculus 
2015-05-13 | E-GEOD-68805 | biostudies-arrayexpress
GenomicsmicroRNAs expression Profiles in plasma from spinal tuberculosis patients and healthy volunteers
microRNAs expression Profiles in plasma from spinal tuberculosis patients and healthy volunteers
PRJNA936992 | ENA
TranscriptomicsTranscriptome analysis of myeloid cells (neutrophils, macrophages and dendritic cells) isolated from the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE)
We have discovered that neutrophils that infiltrate the spinal cord of mice with EAE, a model of multiple sclerosis, but not intravascular neutrophils that crawl on the luminal endothelial surface, bear on their surface the adhesion molecule Icam1. The goal of this experiment was to use Icam1 to iso...
ORGANISM(S): Mus musculus 
2017-11-10 | E-MTAB-6160 | biostudies-arrayexpress
UnknownAnalysis of the Value of Serum Biomarker LBP in the Diagnosis of Spinal Tuberculosis.
Not available
S-EPMC9439074 | biostudies-literature
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