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ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based ...
2024-09-02 | BIOMD0000000187 | BioModels
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering ...
2024-09-02 | BIOMD0000000186 | BioModels
ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
Proteomics19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
During regulated protein degradation, the 26S proteasome recognizes ubiquitinated substrates through its 19S particle and then degrades them in its 20S enzymatic core. Despite this close interdependency between proteasome subunits, we demonstrate that knockouts from different proteasome subcomplexes...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD065357 | Pride
Proteasome Mitosis Spindle Degradation Kinesin Ubiquitin 
GenomicsNitrosopumilus spindle-shaped virus
Nitrosopumilus spindle-shaped viruses (NSV) of genome sequencing and assembly
PRJNA516109 | ENA
GenomicsMethanosarcina spindle-shaped virus 1
Methanosarcina spindle-shaped virus 1 Metagenomic assembly
PRJNA1132277 | ENA
ProteomicsDiscovery of kinetochore and spindle assembly checkpoint proteins in apicomplexan parasites
Kinetochores are multiprotein assemblies that bind chromosomes to the spindle during mitosis. Despite conserved roles, repertoires of kinetochore proteins vary greatly across eukaryotes. In particular, most known components are not clearly detected in a group of parasites known as the Apicomplexa. F...
ORGANISM(S): Plasmodium berghei ANKA 
2023-03-11 | PXD028595 | Pride
Spindle assembly Lc-msms Apicomplexan parasite Immunoprecipitation 
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase JAK2. Expre...
ORGANISM(S): Homo sapiens (Human) 
2024-10-16 | PXD056821 | Pride
Phosphorylation Chk2 Lc-ms/ms 
UnknownPhase transition of spindle-associated protein regulate spindle apparatus assembly.
Not available
S-EPMC4607269 | biostudies-literature
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
This dataset consists of 1 raw MS file and associated peak list and result file, acquired on an Orbitrap Elite mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication. Publication title: "JAK2-CHK2 signaling safeguards the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-31 | MSV000087138 | MassIVE
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