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Transcriptomics22RV1 prostate cancer cell line transfected with SPINK1 siRNA vs control siRNA
ETS gene fusions have been characterized in a majority of prostate cancers, however key molecular alterations in ETS negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier-expression exclusively in a subset of ETS rearrangement negative cancers (~...
ORGANISM(S): Homo sapiens 
2008-06-10 | E-GEOD-11132 | biostudies-arrayexpress
ProteomicsAn integrative proteomics approach to identify novel therapeutic targets for SPINK1-positive prostate cancer.
Dysregulated phosphorylation of proteins perturbs the activity of several biological pathways leading to tumorigenesis and metastases. Integrated proteomics studies offer an in-depth comprehension of cancer pathobiology, and could untangle its complex circuitries. To decipher the signaling involved ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD043086 | Pride
Integrative proteome profiling Prostate cancer Spink1 
TranscriptomicsSPINK1 promotes Colorectal Cancer progression by down regulating Metallothioneins expression
Expression profiling was performed using Agilent Whole Human Genome Oligo Microarray (Santa Clara, CA) according to the manufacturer’s protocol. A total of 3 microarray hybridizations were performed using each stable shSPINK1 cell line samples against control shSCRM cells. SPINK1 gene was knocked do...
ORGANISM(S): Homo sapiens 
2015-07-11 | E-GEOD-70761 | biostudies-arrayexpress
GenomicsGene expression profile of 22RV1 prostate cancer cells upon SPINK1 knockdown
Gene expression profile of 22RV1 prostate cancer cells upon SPINK1 knockdown
PRJNA511709 | ENA
TranscriptomicsGene expression profile of 22RV1 prostate cancer cells upon SPINK1 knockdown
Serine Peptidase Inhibitor, Kazal type 1 (SPINK1) overexpression represents the second-largest prostate cancer (PCa) subtype associated with increased risk of biochemical recurrence and poor prognosis. To determine the pathways regulated by SPINK1 in 22RV1 prostate cancer cells, we performed shRNA m...
ORGANISM(S): Homo sapiens 
2019-12-16 | GSE124345 | GEO
Transcriptomics22RV1 prostate cancer cell line transfected with SPINK1 siRNA vs control siRNA
ETS gene fusions have been characterized in a majority of prostate cancers, however key molecular alterations in ETS negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier-expression exclusively in a subset of ETS rearrangement negative cancers (~1...
ORGANISM(S): Homo sapiens 
2008-06-10 | GSE11132 | GEO
GenomicsPolycomb Group protein EZH2-mediated transcriptional repression of microRNA-338/-421 drives SPINK1-positive prostate cancer
Polycomb Group protein EZH2-mediated transcriptional repression of microRNA-338/-421 drives SPINK1-positive prostate cancer
PRJNA427683 | ENA
TranscriptomicsPolycomb Group protein EZH2-mediated transcriptional repression of microRNA-338/-421 drives SPINK1-positive prostate cancer
SPINK1 overexpression defines the second largest subtype of prostate cancer (PCa), however molecular mechanisms underlying its upregulation remains poorly understood. Here, we identified the role of miR-338-5p and miR-421 in post-transcriptional regulation of SPINK1. We established that miR-338-5p/m...
ORGANISM(S): Homo sapiens 
2018-12-30 | GSE108558 | GEO
UnknownPerformance of SPINK1 and SPINK1-based diagnostic model in detection of hepatocellular carcinoma.
Not available
S-EPMC8605149 | biostudies-literature
GenomicsEffect of SPINK1 and IL-6 knockdown in JHOC9 and JHOC5 ovarian clear cell carcinoma cells
Effect of SPINK1 and IL-6 knockdown in JHOC9 and JHOC5 ovarian clear cell carcinoma cells
PRJNA588561 | ENA
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