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ProteomicsProteomics- and BRET-screens identify SPRY2 as interactor of active Ras the impacts on its membrane organisation
K-Ras is regulated and active in nanoscale proteo-lipid domains of the plasma membrane. Few regulators of K-Ras membrane organisation have been identified so far. We here combined a primary TurboID-based proximal proteome screen with a secondary BRET-screen to identify nine novel bona fide interacto...
ORGANISM(S): Homo sapiens (Human) 
2025-10-02 | PXD067415 | Pride
Turboid Kras Aplp2 Spry2 Bret 
GenomicsGene expression analyses of CWR22Res Nsi (non-silencing) control and with stable knockdown of Sprouty2 (SPRY2)
Gene expression analyses of CWR22Res Nsi (non-silencing) control and with stable knockdown of Sprouty2 (SPRY2)
PRJNA427327 | ENA
UnknownEpigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers.
Not available
S-EPMC8534322 | biostudies-literature
TranscriptomicsSPROUTY2 target genes in human colon carcinoma cells
The role of SPROUTY2 (SPRY2) in human colon cancer is controversial. Our data support a tumorigenic action of SPRY2. We use microarrays to identify SPRY2 target genes in human SW480 ADH colon carcinoma cell line. RNA was obtained from SW480 ADH cells, Mock transfected or transfected with WT or two d...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-56941 | biostudies-arrayexpress
UnknownSpry1 and Spry2 are necessary for eyelid closure.
Not available
S-EPMC3857020 | biostudies-literature
TranscriptomicsGene expression analyses of CWR22Res Nsi (non-silencing) control and with stable knockdown of Sprouty2 (SPRY2)
Effects of SPRY2 deficiency in gene expression of CWR22Res prostate cancer cells.
ORGANISM(S): Homo sapiens 
2018-03-13 | GSE108456 | GEO
UnknownLoss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.
Not available
S-EPMC10375677 | biostudies-literature
UnknownProteomics- and BRET- screens identify SPRY2 as a Ras effector that impacts its membrane organization.
Not available
S-EPMC12682140 | biostudies-literature
UnknownSPRY2 is a novel MET interactor that regulates metastatic potential and differentiation in rhabdomyosarcoma.
Not available
S-EPMC5833614 | biostudies-literature
UnknownSPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis.
Not available
S-EPMC3494076 | biostudies-literature
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