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TranscriptomicsGenome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
SR proteins are well-characterized RNA binding proteins that promote exon inclusion by binding to exonic splicing enhancers (ESEs). However, it has been unclear whether regulatory rules deduced on model genes apply generally to activities of SR proteins in the cell. Here, we report global analyses o...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-44591 | biostudies-arrayexpress
TranscriptomicsKnockdown of SR protein family in P19 cells and RNA-seq of cytoplasmic and whole cell polyA+ RNA
Our data suggest that all SR proteins contribute to mRNA export via NXF1. To identify endogenous export targets we depleted all seven SR proteins individually from P19 WT cells prepared cytoplasmic fractions. We sequenced the cytoplasmic fraction and as a control whole celll RNA from the identical s...
ORGANISM(S): Mus musculus 
2016-03-07 | E-GEOD-69733 | biostudies-arrayexpress
TranscriptomicsA single SR-like protein, Npl3, promotes pre-mRNA splicing in budding yeast
Mammalian SR proteins are a family of reversibly phosphorylated RNA binding proteins primarily studied for their roles in alternative splicing. While budding yeast lack alternative splicing, they do have three SR-like proteins: Npl3, Gbp2, and Hrb1. However, these have been primarily studied for the...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-30 | E-GEOD-11491 | biostudies-arrayexpress
GenomicsSphaerisporangium sp. MMS25-SR-16
Sphaerisporangium sp. MMS25-SR-16 Genome sequencing
PRJNA1517310 | ENA
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
TranscriptomicsSR Proteins Collaborate with 7SK and Promoter-Associated Nascent RNA to Release Paused Polymerase
RNAP II is frequently paused near gene promoters in mammals and its transition to productive elongation requires active recruitment of P-TEFb, a cyclin-dependent kinase for RNAP II and other key transcription elongation factors. A fraction of P-TEFb is sequestered in an inhibitory complex containing...
ORGANISM(S): Mus musculus 
2013-05-09 | E-GEOD-45517 | biostudies-arrayexpress
GenomicsAmmonifex thiophilus strain:SR
Ammonifex thiophilus strain:SR Genome sequencing and assembly
PRJNA484335 | ENA
GenomicsLysinibacillus xylanilyticus strain:SR-86
Lysinibacillus xylanilyticus strain:SR-86 Genome sequencing and assembly
PRJNA338387 | ENA
ProteomicsPDZ domain-containing adaptor protein GIPC1 interacts with the SR-B1 and modulates its expression and lipid transport function
PDZ family protein GIPC1 physically interacts with SR-B1 and regulates SR-B1 expression by promoting SR-B1 protein stability.
ORGANISM(S): Mus Musculus 
2021-03-09 | PXD024595 |
TranscriptomicsThe Nuclear-retained non-coding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate tissue- or cell type-specific AS in a concentration and phosphorylation dependent manner. However, the mechanisms tha...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22963 | biostudies-arrayexpress
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