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Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishm...
ORGANISM(S): Homo sapiens 
Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. To describe these changes, investigators have relied extensively on the study of immortalized rodent cell lines or heterogeneous tumor samples that limit the identification of differentially exp...
ORGANISM(S): Gallus gallus 
Data from MASSIVE, [[http://proteomics.ucsd.edu/ProteoSAFe/datasets.jsp MSV000078499]]. File: K562_P060110_trypsin_09_19_ftt8_ccc_01.mzml. Published as part of Nat Biotechnol. 2009 Jan;27(1):77-83 . From the Abstract: {{i}} ... Here we describe a bead-based method for detecting phosphorylation of b...
ORGANISM(S): Human_adenovirus_54,human_adenovirus_a,human_adenovirus_b,human_adenovirus_c,human_adenovirus_d,human_adenovirus_e,human_adenovirus_f,human_adenovirus_g,human_astrovirus,human_bocavirus,human_bocavirus_2,human_bocavirus_3,human_bocavirus_4,human_coronavirus_229e,human_coronavirus_hku1,human_coronavirus_nl63,human_coronavirus_oc43,human_cosavirus_a,human_cosavirus_b,human_cosavirus_d,human_cosavirus_e,human_enteric_coronavirus_4408,human_enterovirus_100,human_enterovirus_a,human_enterovirus_b,human_enterovirus_c,human_enterovirus_d,human_erythrovirus_v9,human_herpesvirus_1,human_herpesvirus_2,human_herpesvirus_3,human_herpesvirus_4_type_1,human_herpesvirus_4_type_2,human_herpesvirus_5,human_herpesvirus_6a,human_herpesvirus_6b,human_herpesvirus_7,human_herpesvirus_8_type_p,human_immunodeficiency_virus_1,human_immunodeficiency_virus_2,human_metapneumovirus,human_papillomavirus_fa75_ki88_03,human_papillomavirus_rtrx7,human_papillomavirus_type_10,human_papillomavirus_type_100,human_papillomavirus_type_101,human_papillomavirus_type_103,human_papillomavirus_type_104,human_papillomavirus_type_105,human_papillomavirus_type_108,human_papillomavirus_type_109,human_papillomavirus_type_112,human_papillomavirus_type_113,human_papillomavirus_type_16,human_papillomavirus_type_24,human_papillomavirus_type_26,human_papillomavirus_type_32,human_papillomavirus_type_34,human_papillomavirus_type_4,human_papillomavirus_type_41,human_papillomavirus_type_48,human_papillomavirus_type_49,human_papillomavirus_type_5,human_papillomavirus_type_50,human_papillomavirus_type_53,human_papillomavirus_type_60,human_papillomavirus_type_63,human_papillomavirus_type_6b,human_papillomavirus_type_7,human_papillomavirus_type_71,human_papillomavirus_type_88,human_papillomavirus_type_9,human_papillomavirus_type_92,human_papillomavirus_type_96,human_papillomavirus_type_98,human_papillomavirus_type_99,human_papillomavirus___1,human_papillomavirus___18,human_papillomavirus___2,human_papillomavirus___54,human_papillomavirus___61,human_papillomavirus___cand90,human_parainfluenza_virus_1,human_parainfluenza_virus_2,human_parainfluenza_virus_3,human_parechovirus,human_parvovirus_4,human_parvovirus_b19,human_picobirnavirus,human_respiratory_syncytial_virus,human_rhinovirus_a,human_rhinovirus_b,human_rhinovirus_c,human_tmev_like_cardiovirus,human_t_lymphotropic_virus_1,human_t_lymphotropic_virus_2,human_t_lymphotropic_virus_4,simian_adenovirus_a,simian_agent_12,simian_enterovirus_a,simian_enterovirus_sv19,simian_enterovirus_sv43,simian_enterovirus_sv6,simian_foamy_virus,simian_hemorrhagic_fever_virus,simian_human_immunodeficiency_virus,simian_immunodeficiency_virus,simian_immunodeficiency_virus_siv_mnd_2,simian_picornavirus_1,simian_picornavirus_17,simian_picornavirus_n125,simian_t_lymphotropic_virus_1,simian_t_lymphotropic_virus_2,simian_virus_12,simian_virus_40,simian_virus_41,simian_virus_5, Human_female 
Data-dependent nLC-MS/MS analysis of EYA3 phosphorylation by Src protein tyrosine kinase
ORGANISM(S): Homo sapiens (Human) 
2019-12-17 | PXD016518 | Pride
Protein tyrosine phosphorylation (pTyr) is regulated by protein tyrosine phosphatases (PTPs) and27 kinases, helping cells detect and react to environmental changes. Pervanadate is commonly used to increase pTyr levels by inhibiting PTPs, leading to the belief that PTPs are the main regulators of pTy...
ORGANISM(S): Homo sapiens (Human) 
2026-02-05 | PXD059840 | Pride
Data-dependent nLC-MS/MS analysis of EYA3 phosphorylation by Src protein tyrosine kinase
ORGANISM(S): Homo sapiens (Human) 
2019-12-17 | PXD016520 | Pride
Data-dependent nLC-MS/MS analysis of EYA3 phosphorylation by Src protein tyrosine kinase
ORGANISM(S): Homo sapiens (Human) 
2019-12-17 | PXD016526 | Pride
The emergence of anti-estrogen resistance in breast cancer is an important clinical phenomenon affecting long-term survival in this disease. Identifying factors that convey cell survival in this setting may guide improvements in treatment. Estrogen (E2) can induce apoptosis in breast cancer cells th...
ORGANISM(S): Homo sapiens 
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear. Here, we show that proto-oncogene tyrosine kinase c-SRC is activated in glioblastoma and remodel...
ORGANISM(S): Homo sapiens (Human) 
2024-07-29 | PXD054314 | Pride
Secreted protein kinases are responsible for the phosphorylation of a vast number of extracellular phosphoproteins. The tyrosine kinase c-Src is secreted through the vesicular trafficking pathway, however, mechanistic insights into extracellular substrate specificity and potential therapeutic opport...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-05-30 | PXD036069 | Pride
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