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ProteomicsCREB regulated transcriptional coactivator 2 proteome landscape is plausibly modulated by SREBF1
CRTC2 is a critical transcription cofactor that induces the glucose homeostatic genes by activating CREB. However, energy homeostasis is maintained by multiple pathways, therefore, it is possible that CRTC2 may interact with other transcription factors, especially under metabolic stress. Thereby, CR...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD039817 | Pride
Crtc2 Ppi Metabolic disorders Srebf1 Glucose homeostasis 
GenomicsTranscriptome analysis of SREBF1 silencing and overexpression in thyroid cancer cells
Transcriptome analysis of SREBF1 silencing and overexpression in thyroid cancer cells
PRJNA721465 | ENA
GenomicsRNA-seq in SREBF1-deficient human iPSCs, hiPSC-NSCs and differentiated cells.
RNA-seq in SREBF1-deficient human iPSCs, hiPSC-NSCs and differentiated cells.
PRJNA1140208 | ENA
TranscriptomicsEffect of SREBF1 knockdown in glioblastoma stem cells (GSCs)
To investigate the function of SREBF1 in GSCs, we knocked down the expression of SREBF1 by shRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cell lines.
ORGANISM(S): Homo sapiens 
2026-10-07 | GSE205659 | GEO
GenomicsARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes.
ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes.
PRJNA1101577 | ENA
GenomicsARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes
ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes
PRJNA1094961 | ENA
GenomicsTranscriptomic analysis of active form of Srebf1-overexpressed fibroblasts in bleomycin-induced lung fibrosis
Transcriptomic analysis of active form of Srebf1-overexpressed fibroblasts in bleomycin-induced lung fibrosis
PRJNA433942 | ENA
UnknownSREBF1-based metabolic reprogramming in prostate cancer promotes tumor ferroptosis resistance.
Not available
S-EPMC11847930 | biostudies-literature
GenomicsSREBF1 coordinates with master transcription factors in regulating lipid metabolism and cancer-promoting pathways in squamous cell carcinoma [4C]
SREBF1 coordinates with master transcription factors in regulating lipid metabolism and cancer-promoting pathways in squamous cell carcinoma [4C]
PRJNA741506 | ENA
TranscriptomicsRNA-seq in SREBF1-deficient human iPSCs, hiPSC-NSCs and differentiated cells.
Omics analyses and qRT-PCR time-course during the transition from hiPSC to hiPSC-NSC highlighted the up-regulation of SREBF1, a gene involved in cholesterol biosynthesis and lipid homeostasis, suggesting its potential role in NSC commitment/maintenance. To test this hypothesis, we generated SREBF1-d...
ORGANISM(S): Homo sapiens 
2024-09-23 | GSE273125 | GEO
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