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RGG motif-containing proteins are the second largest group of RNA-binding proteins. Here, we identify a unique and conserved role of yeast Scd6 and its human ortholog LSM14A in hydroxyurea (HU)-mediated genotoxic stress response. Scd6/LSM14A, but not all tested RGG-containing proteins, localize to c...
ORGANISM(S): Homo sapiens 
2025-06-04 | GSE274294 | GEO
RGG motif-containing Scd6/LSM14A proteins regulate the translation of specific mRNAs in response to hydroxyurea-induced genotoxic stress
Homologous recombination is essential for high-fidelity DNA repair during mitotic proliferation and meiosis. Yet, context-specific modifications must tailor the recombination machinery to avoid, or enforce, formation of reciprocal exchanges – crossovers – between recombining chromosomes. To obtain m...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-07-31 | PXD012486 | Pride
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