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TranscriptomicsEffects of knockdown of ROCK1 and ZIPK on gene expression in cultured human vascular smooth muscle cells
Rho-associated kinase (ROCK) and zipper-interacting protein kinase (ZIPK) have been implicated in diverse physiological functions, including smooth muscle contraction, cell proliferation, cell adhesion, apoptosis, cell migration and inflammation. Many aspects of regulation via ROCK and ZIPK, however...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-56819 | biostudies-arrayexpress
TranscriptomicsThe epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate alternative splicing events
Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2) are recently discovered epithelial-specific RNA-binding proteins that promote splicing of the epithelial variant of the FGFR2, ENAH, CD44, and CTNND1 transcripts. To catalogue a larger set of splicing events under the regulation of t...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17468 | biostudies-arrayexpress
TranscriptomicsShp2 transcriptome in melanoma
1205Lu Metastatic Human melanoma cell lines with knockdown of Shp2 (PTPN11) were grown as xenograft tumors in NSG mice. RNA was extracted from the tumors and analyzed on [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] Shp2 knockdown compared with non-target controls
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-53282 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of SGTA knockdown in C4-2B prostate cancer cells
Identifying the effect of the co-chaperone SGTA on global androgen receptor transcriptional activity in C4-2B prostate cancer cells with view to further elucidating the broader biological role of SGTA on other signaling pathways within prostate cancer cells Knockdown of SGTA for 72 hours in C4-2B ce...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-43521 | biostudies-arrayexpress
TranscriptomicsA specialized mechanism of translation mediated by FXR1a-associated microRNP in cellular quiescence
MicroRNAs predominantly decrease gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes by an FXR1a-associated microRNP (microRNA-protein complex) that lacks the microRNP repressor, GW182. We conducted global pro...
ORGANISM(S): Homo sapiens 
2016-02-03 | E-GEOD-77512 | biostudies-arrayexpress
TranscriptomicsGene Expression in Castration-Resistant C4-2 Cells after AR Knockdown
Prostate cancer is the most common, lethal malignancy in men. Although androgen withdrawal therapies are used to treat advanced disease, progression to a castration-resistant, end-stage is the usual outcome. In this study, the tested hypothesis was that the androgen receptor remains essential for th...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-13332 | biostudies-arrayexpress
TranscriptomicsExpression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures
The objective of this experiment was to determine global gene expression change in triple negative cell line upon knockdown of TGFBR3. Genotype specific differences in expression profiles have been evaluated using human HuGene1.0-ST affymetrix array. RNA was extracted from SUM159 controls and SUM1...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-54756 | biostudies-arrayexpress
TranscriptomicsExpression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures
The objective of this experiment was to determine global gene expression change in triple negative cell line upon knockdown of TGFBR3. Genotype specific differences in expression profiles have been evaluated using human HuGene1.0-ST affymetrix array. RNA was extracted from SUM159 controls and SUM159...
ORGANISM(S): Homo sapiens 
2014-02-06 | GSE54756 | GEO
TranscriptomicsThe DNMT1 associated lncRNA Dali is an epigenetic regulator of neural differentiation [3]
Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent protein coding genes. Less clear is whether intergenic lncRNAs commonly regulate transcription by modulating chromatin at genomically distant loci. Here, we report both genomically local and distal RNA-dependent rol...
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-62033 | biostudies-arrayexpress
TranscriptomicsThe DNMT1 associated lncRNA Dali is an epigenetic regulator of neural differentiation [1]
Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent protein coding genes. Less clear is whether intergenic lncRNAs commonly regulate transcription by modulating chromatin at genomically distant loci. Here, we report both genomically local and distal RNA-dependent rol...
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-62031 | biostudies-arrayexpress
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