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MetabolomicsStable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture
Xenobiotics are ubiquitous in the environment and modified abundantly in the human body by phase I and II metabolism. Liquid chromatography coupled to high resolution mass spectrometry is a powerful tool to investigate these biotransformation products. Here, we present a workflow based on stable iso...
2020-04-14 | MTBLS1358 | MetaboLights
MetabolomicsElucidation of xenoestrogen metabolism by non-targeted, stable isotope-assisted mass spectrometry in breast cancer cells

Environmental exposure to xenoestrogens, i.e., chemicals that imitate the hormone 17β-estradiol, has the potential to influence hormone homeostasis and action. Detailed knowledge of xenobiotic biotransformation processes in cell models is key when transferring knowledge learned from in vitro<...

2023-10-26 | MTBLS2716 | MetaboLights
MetabolomicsMatrix Effect on Chemical Isotope Labeling and Its Implication in Metabolomic Sample Preparation for Quantitative Metabolomics
Matrix effect from various constituents in biological samples can reduce the accuracy of quantitative metabolomics. Differential chemical isotope labeling liquid chromatography mass spectrometry (CIL LC-MS) can overcome the matrix effect on MS detection based on measuring the intensity ratios of met...
2015-07-01 | MTBLS194 | MetaboLights
MetabolomicsComposition of the marine exometabolome is more stable than the functionally redundant microbial community in the oligotrophic North Atlantic

Untargeted features from the Bermuda Atlantic Time-series Study (BATS) site collected during the time period spanning 2016 to 2019. Metabolites were sampled from surface seawater to 1000 m deep and throughout the year. Dissolved organic matter extracts were analyzed in positive and negative ion m...

2024-02-28 | MTBLS5228 | MetaboLights
UnknownRelative quantification of serum proteins from pancreatic ductal adenocarcinoma patients by stable isotope dilution liquid chromatography-mass spectrometry.
Not available
S-EPMC3292696 | biostudies-literature
UnknownStable isotope dilution mass spectrometry quantification of hydrogen sulfide and thiols in biological matrices.
Not available
S-EPMC9307673 | biostudies-literature
UnknownStable Isotope Dilution Analysis of the Major Prenylated Flavonoids Found in Beer, Hop Tea, and Hops.
Not available
S-EPMC7770140 | biostudies-literature
Proteomics13C15N – Glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans
Glucagon serves as an important regulatory hormone for regulating blood glucose concentrations with tight feedback control with insulin and glucose. There are critical gaps in our understanding of glucagon kinetics, pancreatic α cell function and intra-islet feedback network that are disrupted in ty...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD028715 | Pride
Glucagon Prm Stable isotope dilution Lc-ms/ms 
UnknownSimultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry.
Not available
S-EPMC7359880 | biostudies-literature
UnknownMicroalgae a Superior Source of Folates: Quantification of Folates in Halophile Microalgae by Stable Isotope Dilution Assay.
Not available
S-EPMC6985443 | biostudies-literature
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