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UnknownChronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.

Objective

To determine the relation between markers of kidney disease-estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR)-with cerebral blood flow (CBF) and white matter volume (WMV) in hypertensive adults.

Methods

We used baseline data collected f...
S-EPMC4818564 | biostudies-literature
UnknownElective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Purpose

As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary compli...
S-EPMC8189635 | biostudies-literature
UnknownSafety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.
Not available
S-EPMC7445431 | biostudies-literature
UnknownFinal Report of a Trial of Intensive versus Standard Blood-Pressure Control.

Background

In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated and post-trial follow-up data had not yet been collected.

Methods

We randomly assigned 9361 participants who were at in...
S-EPMC9907774 | biostudies-literature
UnknownAssociation of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial.

Importance

Meta-analyses of randomized clinical trials have indicated that improved hypertension control reduces the risk for cognitive impairment and dementia. However, it is unclear to what extent pathways reflective of Alzheimer disease (AD) pathology are affected by hypertension control....
S-EPMC7941253 | biostudies-literature
Unknown18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.
Background: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction...
S-EPMC5849499 | biostudies-literature
UnknownEffect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes.

Background

The previously published results of the Systolic Blood Pressure Intervention Trial showed that among participants with hypertension and an increased cardiovascular risk, but without diabetes, the rates of cardiovascular events were lower among those who were assigned to a target s...
S-EPMC5706112 | biostudies-literature
UnknownKidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

Rationale & objective

The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in individuals with and without CKD.

Study design

Neuroimaging...
S-EPMC8926938 | biostudies-literature
UnknownA Randomized Trial of Intensive versus Standard Blood-Pressure Control.

Background

The most appropriate targets for systolic blood pressure to reduce cardiovascular morbidity and mortality among persons without diabetes remain uncertain.

Methods

We randomly assigned 9361 persons with a systolic blood pressure of 130 mm Hg or higher and an increased cardio...
S-EPMC4689591 | biostudies-literature
UnknownEffect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization.

Background

Patients hospitalized with COVID-19 have an increased incidence of thromboembolism. The role of extended thromboprophylaxis after hospital discharge is unclear.

Objective

To determine whether anticoagulation is superior to placebo in reducing death and thromboembolic compli...
S-EPMC10064277 | biostudies-literature
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