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ProteomicsSpatial tissue proteomics analysis of laser capture microdisscted intestinal crypt compartment
Crypt hyperplasia is a key feature of celiac disease and various other small intestinal inflammatory conditions. By undertaking mass spectrometry-based tissue proteomics of the gut epithelial crypt zone, we found that active celiac disease is characterized by a strong interferon-γ (IFN-γ) signal. Th...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD062684 | Pride
Mouse Intestine Interferon-gamma Crypt hyperplasia 
ProteomicsSpatial tissue proteomics analysis of laser capture microdisscted intestinal crypt compartment in celiac disease
Crypt hyperplasia is a key feature of celiac disease and various other small intestinal inflammatory conditions. By undertaking mass spectrometry-based tissue proteomics of the gut epithelial crypt zone, we found that active celiac disease is characterized by a strong interferon-γ (IFN-γ) signal. Th...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD062610 | Pride
Intestine Spatial proteomics Human Celiac disease 
ProteomicsCharacterization of the small intestinal lesion in celiac disease by label-free quantitative mass spectrometry
This study describes a comparison of global proteome expression in small intestinal tissue collected from celiac disease patients at different stages of disease. We have analyzed sections from FFPE biopsy blocks and identified more than 4500 protein without sample pre-fractionation. We have compared...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD008992 | Pride
Human Small intestine Ffpe Celiac disease Label-free quantification Shot-gun proteomics 
ProteomicsBiopsy proteome score performs well as an effect measure in a gluten-challenge trial of coeliac disease
Objective Development of novel treatments for coeliac disease (CeD) is dependent on precise tools to monitor changes in gluten-induced mucosal damage. Current histology measures are subjective and difficult to standardise. Biopsy proteome scoring is an objective alternative to histology which is bas...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD050655 | Pride
Human Proteome score Gut biopsy Evosep Timstofflex Clinical trial 
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