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ProteomicsComparative analysis of T cell receptor and chimeric antigen receptor signaling in primary CD8+ T cells
Chimeric antigen receptor-modified (CAR) T cell therapy targeting highly expressed lineage antigens is effective for B cell malignancies. Achieving durable efficacy for hematological malignancies and extending this therapeutic approach to solid tumors will require T cell recognition and elimination ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-20 | PXD013734 | Pride
Chimeric antigen receptor T cell T cell receptor Immunotherapy Phosphoprotein signaling 
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
ProteomicsO-Fucose glycans on mouse NOTCH1 from activated T cells of Fringe mutant mice
NOTCH1 (N1) is a transmembrane receptor that initiates a cell-cell signaling pathway controlling various cell fate specifications in metazoans. The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD031297 | Pride
T cell Notch1 O-fucose Fringe Pofut1 
ProteomicsGlobal phosphoproteomic analysis of signaling by distinct chimeric antigen receptors reveals kinetic and quantitative differences that influence cell function
Chimeric antigen receptors (CARs) are synthetic proteins that redirect T cell specificity by linking an extracellular ligand binding domain to intracellular T cell signaling domains. CAR-expressing T (CAR-T) cells have demonstrated significant efficacy for the treatment of refractory B cell malignan...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD007921 | Pride
Imac enrichment T cell Chimeric antigen receptor Phosphoprotein signaling Primary t cell Basic reverse phase fractionation Phosphoproteomics Lc-ms/ms 
TranscriptomicsGene expression profiling of human CD8+ CD161hi and CD161lo memory and naïve T cell subsets
Gene expression profiling of human CD8+ CD161hi and CD161lo central and effector memory and naïve T cell subsets. The mechanisms by which IL-17 secreting cells are regulated have not been completely elucidated. We previously identified a population of rhodamine-effluxing memory CD8+ T cells with hi...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-23663 | biostudies-arrayexpress
TranscriptomicsExpression data from IL-10+ and IL-10- CD8 T cells
IL-10 is an anti-inflammatory cytokine that has been shown to be produced by antigen-specific CD8 T cells at the peak of viral encephalitis. We found that IL-10+CD8 T cells are more activated and cytolytic than IL-10-CD8 T cells. We used microarrays to detect gene expression changes in directly ex v...
ORGANISM(S): Mus musculus 
2010-12-07 | E-GEOD-25846 | biostudies-arrayexpress
GenomicEndogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer, including KRAS and Her2

Neoantigen-specific T cell responses were characterized in 4 patients with non-small cell lung cancer. Candidate neoantigens were identified by sequencing tumor and normal DNA from each patient, and ranking single nucleotide variants by expression. Multiple T cell responses were isolated, and in ...

phs001805 | dbGaP
UnknownT cells conditioned with MDSC show an increased anti-tumor activity after adoptive T cell based immunotherapy.
Not available
S-EPMC4951233 | biostudies-literature
UnknownRescue of notch-1 signaling in antigen-specific CD8+ T cells overcomes tumor-induced T-cell suppression and enhances immunotherapy in cancer.
Not available
S-EPMC4125513 | biostudies-literature
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