Sort   by:  
 Page size 
TranscriptomicsMouse MOV10L1 associates with Piwi proteins and is an essential component of the piRNA pathway
Piwi-interacting RNAs (piRNAs) are essential for silencing of transposable elements in the germline but their biogenesis is poorly understood. Here we demonstrate that MOV10L1, a germ cell-specific putative RNA helicase, is associated with Piwi proteins. Genetic disruption of the MOV10L1 RNA helicas...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-21763 | biostudies-arrayexpress
ProteomicsDevelopmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers
Using CRISPR-Cas9 to tag endogenous remodeler subunits in Drosophila melanogaster S2 cells, we demonstrate that developmental gene transcription requires SWI/SNF-type complexes, primarily to maintain distal enhancer accessibility.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-24 | PXD036007 | Pride
Brd7 Chromatin remodelers Swi/snf Drosophila Transcription 
no omics definedRNAi knock down of GW182 in Drososphila cells compared to cells with knock down of AGO1, a key effector of miRNA-mediated gene silencing
RNA silencing pathways are conserved gene regulation mechanisms that lead to degradation, translational repression or transcriptional silencing of target-transcripts selected based on complementarity with small RNA molecules. Using firefly luciferase reporters, we previously were able show that the ...
ORGANISM(S): Drosophila melanogaster 
2006-10-31 | E-MEXP-487 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of four Argonaute paralogs (AGO1, AGO2, PIWI and Aubergine) and the microRNA-processing enzyme Drosha in Drosophila
RNA silencing pathways are conserved gene regulation mechanisms that lead to degradation, translational repression or transcriptional silencing of target-transcripts selected based on complementarity with small RNA molecules. The fraction of the genome regulated by these pathways has not been establ...
ORGANISM(S): Drosophila melanogaster 
2006-11-20 | E-MEXP-295 | biostudies-arrayexpress
UnknownSoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system.
Not available
S-EPMC8263579 | biostudies-literature
UnknownThe impact of passive alveolar molding vs. nasoalveolar molding on cleft width and other parameters of maxillary growth in unilateral cleft lip palate.
Not available
S-EPMC10492684 | biostudies-literature
ProteomicsClassically-activated macrophages rely on glucose-derived glycerol and external fatty acid for TAG synthesis
Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro-inflammatory activation of macrophages remains inco...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD017148 | Pride
Infection Tag Macrophages 
GenomicsChIP-Seq of six Drosophila species with anti-Drosophila melanogaster Twist and anti-Snail antibodies using different library fragment sizes
The binding patterns of some transcription factors have been shown to diverge substantially between closely related species. Here, we show that the binding pattern of the developmental transcription factor Twist is highly conserved across six Drosophila species, revealing strong functional constrain...
ORGANISM(S): Drosophila ananassae 
2010-12-07 | E-MTAB-376 | biostudies-arrayexpress
TranscriptomicsGenome-wide quantitative enhancer activity maps identified by STARR-seq
Genomic enhancers are important regulators of gene expression, but their identification is a challenge and methods depend on indirect measures of activity. We developed a method termed STARR-seq to directly and quantitatively assess enhancer activity for millions of candidates from arbitrary sources...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-40739 | biostudies-arrayexpress
ProteomicsPromoter DNA-affinity purification
We have identified the protein binders of functionally distinct promoters from the Drosophila melanogaster genome using nuclear extracts prepared from Schneider S2 cells
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-02-16 | PXD028090 | Pride
Drosophila Promoters 
Sort   by:  
 Page size