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GenomicsStart codon-associated ribosomal frameshifting mediates nutrient stress adaptation
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
PRJNA766610 | ENA
ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054179 | Pride
Translation Ribosomes Mitosis Cell cycle 
ProteomicsNuclear release of eIF1 globally increases stringency of start codon selection to preserve mitotic arrest physiology
Regulated start codon selection has the potential to reshape the proteome through the differential production of uORFs, canonical proteins, and alternative translational isoforms. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-07 | PXD054183 | Pride
Translation Ribosomes Mitosis Cell cycle 
TranscriptomicsQuality control of transcription start site selection by Nonsense-Mediated-mRNA Decay
Nonsense-mediated mRNA decay (NMD) is a translation-dependent RNA quality-control pathway targeting transcripts such as messenger RNAs harboring premature stop-codons or short upstream open reading frame (uORFs). Our transcription start sites (TSSs) analysis of Saccharomyces cerevisiae cells deficie...
ORGANISM(S): Saccharomyces cerevisiae BY4741 
2015-04-24 | E-GEOD-64139 | biostudies-arrayexpress
ProteomicsConformational rearrangements upon start codon recognition in human 48S translation initiation complex
Selection of the translation start codon is a key step during protein synthesis in human cells. We obtained cryo-EM structures of human 48S initiation complexes and characterized the intermediates of codon recognition by kinetic methods using eIF1A as a reporter. Both approaches capture two distinct...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031985 | Pride
Ribosome 48s initiation comples Eif1 
GenomicsNuclear release of eIF1 restricts start-codon selection during mitosis
Nuclear release of eIF1 restricts start-codon selection during mitosis
PRJNA957808 | ENA
GenomicsBi-directional ribosome scanning controls the stringency of start codon selection
Bi-directional ribosome scanning controls the stringency of start codon selection
PRJNA734658 | ENA
GenomicsEvolutionarily Conserved Inhibitory uORFs Sensitize Hox mRNA Translation to Start Codon Selection Stringency
Evolutionarily Conserved Inhibitory uORFs Sensitize Hox mRNA Translation to Start Codon Selection Stringency
PRJNA764906 | ENA
ProteomicsAlternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease
Mitochondrial acquisition was a pivotal event in eukaryotic evolution, requiring core proteins adapt to function both within the mitochondria and in the host cell. Here, we systematically profile the localization of protein isoforms generated by alternative start codon selection. We identify hundred...
ORGANISM(S): Homo sapiens (Human) 
2025-10-28 | PXD062112 | Pride
Mrps38 Ribosomes Mitochondria Aurkaip1 
TranscriptomicsStart codon-associated ribosomal frameshifting mediates nutrient stress adaptation
A translating ribosome is typically thought to follow the reading frame defined by the selected start codon. Using super-resolution ribosome profiling, here we report pervasive out-of-frame translation from the start codon. Unlike programmable frameshifting during elongation, start codon-associated ...
ORGANISM(S): Homo sapiens Mus musculus 
2023-03-01 | GSE184825 | GEO
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