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ProteomicsSystematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
We previously reported that Parkinson’s disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (Steger, Tonelli et al., 2016) (PMID: 26824392). Here, we systematically analyzed the Rab protein family and found 14 of them (Rab3A/B/C/D, Rab5A...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-11-14 | PXD007214 | Pride
Proteomics Rabgtpases Lrrk2 Parkinson's disease 
ProteomicsPhosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases
Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson’s disease (PD). G2019S, the most common amino acid substitution activates the kinase two to three-fold. This has motivated the development of LRRK2 kinas...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-02-04 | PXD003071 | Pride
Lrrk2 Substrates Phosphoproteomics Rab gtpases 
UnknownIsolation and structural characterization of a new tadalafil analog (2-hydroxyethylnortadalafil) found in a dietary supplement.
Not available
S-EPMC4934616 | biostudies-literature
TranscriptomicsSurface topography guides morphology and spatial patterning of induced pluripotent stem cell colonies
The relevance of topographic cues for commitment of induced pluripotent stem cells (iPSCs) is largely unknown. In this study, we demonstrate that groove-ridge structures with a periodicity in the submicrometer range induce elongation of iPSC colonies, guide the orientation of apical actin fibers, an...
ORGANISM(S): Homo sapiens 
2018-10-31 | E-MTAB-7327 | biostudies-arrayexpress
GenomicsIntegrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver [ChIP-seq]
Metabolic homeostasis in mammals critically depends on the regulation of fasting-induced genes by CREB in the liver. Previous genome-wide analysis has shown that only a small percentage of CREB target genes are induced in response to fasting-associated signaling pathways. The precise molecular mecha...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-45674 | biostudies-arrayexpress
UnknownTelemedical monitoring in patients with inborn cardiac disease - experience of a tertiary care centre.
Not available
S-EPMC9734484 | biostudies-literature
UnknownSystematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Not available
S-EPMC5695910 | biostudies-literature
GenomicsPropagation of Adipogenic Signals through an Epigenomic Transition State
The transcriptional mechanisms by which temporary exposure to developmental signals instigates adipocyte differentiation are unknown. During early adipogenesis, we find transient enrichment of the glucocorticoid receptor (GR), CCAAT/enhancer binding protein b (CEBPb), p300, mediator subunit 1, and h...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-21898 | biostudies-arrayexpress
GenomicsEpigenome in brown and white adipose tissue
For comparative epigenomic analysis of brown fat and white fat in mice, H3K27ac and PolII ChIP-seq were performed in each depot. H3K27ac histone modification and PolII transcription profiles in mouse brown and white adipose tissues
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63964 | biostudies-arrayexpress
TranscriptomicsAntidiabetic Rosiglitazone Remodels the Adipocyte Transcriptome by Redistributing Transcription to PPARg-Driven Enhancers [HTS]
Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its widespread clinical use. Rosi functions as a high-affinity ligand for PPARg, the adipocyte-predominant nuclear receptor (NR). The classic model, involving binding of ligand to the NR on DNA, explains p...
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-56745 | biostudies-arrayexpress
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