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TranscriptomicsIdentification of genes specific to mouse primordial germ cells through dynamic global gene expression
The molecular mechanisms underlying the commitment of cells to the germ cell lineage and the subsequent formation of germ cells during mammalian development remain poorly understood due to an inability to obtain sufficient amounts of cellular materials to conduct thorough in-vitro analyses. Although...
ORGANISM(S): Mus musculus 
2010-11-16 | E-GEOD-23322 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Fibroblasts into Epiblast Stem Cells
Embryonic stem cells (ESCs), which are derived from the primitive ectoderm of pre-implantation blastocysts, are pluripotent cells and can thus contribute to the formation of all somatic cell lineages in chimeric animals. Similarly, epiblast stem cells (EpiSCs), which are derived from epiblast tissu...
ORGANISM(S): Mus musculus 
2010-12-08 | E-GEOD-21516 | biostudies-arrayexpress
TranscriptomicsEpiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages
Embryonic stem cells (ESCs) comprise at least two populations of cells with divergent states of pluripotency. Here, we show that epiblast stem cells (EpiSCs) also comprise two distinct cell populations that can be distinguished by the expression of a specific Oct4-GFP marker. These two subpopulation...
ORGANISM(S): Mus musculus 
2011-02-24 | E-GEOD-17984 | biostudies-arrayexpress
TranscriptomicsHuman PGC commitment shares key gene dynamics to mouse, but owns a unique PRDM14 expression pattern
The molecular mechanisms of human primordial germ cell (PGC) specification are poorly understood due to the inaccessibility of cell materials and the lack of an alternative in vitro model that enables tracking of the earliest stages of germ cell development. Here, we introduce a defined and efficie...
ORGANISM(S): Homo sapiens 
2015-04-06 | E-GEOD-53498 | biostudies-arrayexpress
TranscriptomicsInduction of Pluripotency in Adult Unipotent Germline Stem Cells
Mouse and human stem cells with features similar to those of embryonic stem cells have been derived from testicular cells. Although pluripotent stem cells have been obtained from defined germline stem cells (GSCs) of mouse neonatal testis, only multipotent stem cells have been obtained so far from d...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16178 | biostudies-arrayexpress
UnknownPhenotypic spectrum in recessive STING-associated vasculopathy with onset in infancy: Four novel cases and analysis of previously reported cases.
Not available
S-EPMC9583393 | biostudies-literature
TranscriptomicsReprogramming of two somatic nuclei in the same ooplasm leads to pluripotent embryonic stem cells
We provide proof that the oocyte is able to reprogram two somatic nuclei at once and therefore is not limited in its reprogramming capacity to a single nucleus. Mouse ooplasts transplanted with 2 somatic cell nuclei simultaneously (double nuclear transfer) support preimplantation development and the...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-36468 | biostudies-arrayexpress
TranscriptomicsSox2 Levels Define Pluripotent Ground States and Reprogramming Potential
Pluripotent stem cell lines derived from embryos of different stages have distinct pluripotent ground states, but similar levels of the transcription factor Oct4. Epiblast-derived pluripotent stem cells (EpiSCs), in contrast to embryonic stem (ES) cells, cannot form chimeras. We show that EpiSCs exp...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-15358 | biostudies-arrayexpress
UnknownVanzacaftor-tezacaftor-deutivacaftor versus elexacaftor-tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials.
Not available
S-EPMC12184100 | biostudies-literature
UnknownExpanded encyclopaedias of DNA elements in the human and mouse genomes.
Not available
S-EPMC7410828 | biostudies-literature
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