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GenomicsHistone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes [ChIP-seq]
The molecular signature at histone H3K4 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3 and H3K4ac histone modification associated with active chromatin to provide...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-69377 | biostudies-arrayexpress
TranscriptomicsHistone H3 lysine 4 acetylation-methylation dynamics define breast cancer subtypes [RNA-seq]
The onset and progression of breast cancer are linked to genetic and epigenetic changes that alter the normal programming of cells. Epigenetic modifications of DNA and histones contribute to chromatin structure that results in the activation or repression of gene expression. Several epigenetic pathw...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-75168 | biostudies-arrayexpress
ProteomicsMedulloblastoma LC-MS/MS using small extracellular vesicles from blood plasma, CSF, and MB cell lines
Liquid biopsy is increasingly recognized for tumor diagnosis and monitoring, and in medulloblastoma (MB) and other CNS tumors, it offers the potential to bypass invasive tissue collection. However, its application in clinical practice remains limited, in part because the optimal choice of biofluid i...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD067299 | Pride
Lc-ms/ms Medulloblastoma Medulloblastoma cell lines Blood plasma Small extracellular vesicles Csf 
TranscriptomicsHashing (sample multiplexing) of MCF7, PC3, DU145 and MDA-MB-231 cells and nuclei using different hashing methods
Evaluate and compare different hashing methods
ORGANISM(S): Homo sapiens 
2021-11-24 | E-MTAB-9964 | biostudies-arrayexpress
GenomicsBivalency - Histone H3 Lysine4 and Histone H3 Lysine27 Methylation Dynamics
The molecular signature at histone H3K4me3 and H3K27me3 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3, associated with active chromatin, and H3K27me3, associated...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-77772 | biostudies-arrayexpress
GenomicsGenome-wide changes in DNase-hypersensitivity during osteoblastogenesis reveal differential usage of DNA motifs and define novel cis-regulatory regions that control gene expression during differentiation [DNase-Seq]
Gene regulation during the process of osteoblastogenesis has been well-described, yet the discovery of novel regulatory regions has been limited by how we currently predict the locations of functional cis-regulatory modules. Historically, the de novo identification of sequences critical for the con...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-55046 | biostudies-arrayexpress
GenomicsWhole exome sequencing analyses of human, IDH2-mutated, acute myeloid leukemia samples from patients before or during treatment with Enasidenib.
Mutations in isocitrate dehydrogenase 2 (IDH2) occur in many cancers including Acute Myeloid Leukemia (AML). In preclinical models mutant IDH2 causes partial hemopoietic differentiation arrest. Recently, we showed that single agent Enasidenib, a first-in-class, selective mutant IDH2 inhibitor, produ...
ORGANISM(S): Homo sapiens 
2018-08-13 | E-MTAB-6299 | biostudies-arrayexpress
GenomicsHistone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-75169 | biostudies-arrayexpress
UnknownBeyond total depressive symptoms: Differential associations between depressive domains, HIV status and disease characteristics.
Not available
S-EPMC12403146 | biostudies-literature
UnknownTemporal Trends in Mitral Valve Repair Procedures and Outcomes Among Older U.S. Adults.
Not available
S-EPMC13634761 | biostudies-literature
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