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ProteomicsNovel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation
Monitoring protein synthesis is essential to our understanding of gene expression regulation, as protein abundance is thought to be predominantly controlled at the level of translation. Mass-spectrometric and RNA sequencing methods have been recently developed for investigating mRNA translation at a...
ORGANISM(S): Homo sapiens (Human) 
2019-02-18 | PXD012727 | Pride
Translatome Ribosome Punch-p 
ProteomicshnRNP C is a key regulator of protein synthesis in mitosis
Stringent post-transcriptional regulation of mRNA fate is critical for proper cell division. To detect proteins involved in such regulation, we analyzed the composition of intact polysomal complexes from mitotic and interphase cells by quantitative mass-spectrometry. Using this approach, we detected...
ORGANISM(S): Homo sapiens (Human) 
2017-07-11 | PXD004244 | Pride
Ribosomes Proteomics Cell cycle Mitosis Silac Translation 
ProteomicsUncovering hidden layers of cell cycle regulation through integrative multi-omic analysis
Studying the complex relationship between transcription, translation and protein degradation is essential to our understanding of biological processes in health and disease. The limited correlations observed between mRNA and protein abundance suggest pervasive regulation of post-transcriptional step...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080771 | MassIVE
ProteomicsUncovering hidden layers of cell cycle regulation through integrative multi-omic analysis
Studying the complex relationship between transcription, translation and protein degradation is essential to our understanding of biological processes in health and disease. The limited correlations observed between mRNA and protein abundance suggest pervasive regulation of post-transcriptional step...
ORGANISM(S): Homo sapiens (Human) 
2015-09-30 | PXD002802 | Pride
Protein expression Cell cycle Proteome Translatome 
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