Sort   by:  
 Page size 
MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
TranscriptomicsTranscription profiling of human hematopoietic stem cells
Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of critical questions of stem cell biology. Microarray studies showed that the HSC supportive mouse fetal liver CD3+ cells specifically expressed angiopoietin-like 2 (...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3609 | biostudies-arrayexpress
ProteomicsThe multi-omic atlas of the exosomes released by human lung adenocarcinoma stem-like cells
Lung adenocarcinoma is heterogeneous and hierarchically organized, with a sub-population of stem-like cells (CSC) that reside at the apex of the hierarchy, in which exosomes act as important mediators by transporting specific molecules among different cell populations. Although there have been numer...
ORGANISM(S): Homo Sapiens 
2021-02-09 | PXD023981 |
TranscriptomicsTranscription profiling of human mesenchymal stem cells reveals carcinoma associated fibroblast like differentiation
Carcinoma associated fibroblasts (CAFs) have recently been implicated in important aspects of epithelial solid tumor biology such as neoplastic progression, tumor growth, angiogenesis, and metastasis. However, neither the source of CAFs nor the differences between CAFs and fibroblasts from non-neopl...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9764 | biostudies-arrayexpress
GenomicsNANOG metabolically reprograms tumor-initiating stem-like cells in oxidative phosphorylation and fatty acid metabolism
Stem cell markers such as NANOG have been implicated in various cancers; however, the functional contribution of NANOG to cancer pathogenesis has remained unclear. In the present study, we show that Toll-like receptor 4 (TLR4) signaling phosphorylates E2F1 to transactivate NANOG. Down-regulation of ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-68237 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells
The differentiation of pluripotent stem cells to hepatocyte-like cells offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of hepatic-like cells (HLC) remains controversial. To obtain an unbiased characterization, we performed a transcriptomics st...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-MTAB-4442 | biostudies-arrayexpress
ProteomicsCalcitriol promotes differentiation of glioma stem-like cells and increases their susceptibility to temozolomide
Cancer cells with a stem-like phenotype are commonly described in glioblastoma, the most common primary adult brain cancer, that are thought to be highly tumorigenic. This phenotype comprimes high self renewal capacity and resistance against chemotherapy and radiation therapy, thereby promoting tumo...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD026789 | Pride
Calcitriol  vitamin d3  glioblastoma  glioblastoma stem-like cells 
Sort   by:  
 Page size