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TranscriptomicsLiver tumor/normal pairs
A major challenge to the study of tumor DNA copy number (CN) in clinical specimens is the lack of appropriate fresh frozen samples and thus a dependence on Formalin-Fixed Paraffin Embedded (FFPE) banked samples, which typically have more extensive clinical follow up information. However, on most hi...
ORGANISM(S): Homo sapiens 
2009-01-22 | E-GEOD-14353 | biostudies-arrayexpress
GenomicsH3K4me3 modification analysis comparing Lsh WT and Lsh-/- MEFs
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29393 | biostudies-arrayexpress
TranscriptomicsGene expression array assay of Lsh WT and Knockout MEF cells
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate cancer cells, normal epithelial prostatic cells and stroma cells from patients in placebo, selenium, vitamin E or selenium and vitamin E treatment groups
85 radical prostatectomy specimens (where 16 samples are in Placebo group (PL), 15 are in Selenium group (SE), 25 are in Vitamin E group (VE) and 27 are in Vitamin E & Selenium group (VS.Treatment groups: l-selenomethionine, 400 ug + placebo (vitamin E); vitamin E, 400 IU + placebo (l-selenomethion...
ORGANISM(S): Homo sapiens 
2008-07-01 | E-MEXP-1327 | biostudies-arrayexpress
TranscriptomicsComprehensive genomic map of cytosine methylation for wild-type (WT) and Lsh-/- mouse embryonic fibroblasts
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29394 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Plasmodium falciparum after exposing drug-selected mutants to short term CQ treatment
Mutations in PfCRT confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels of CQ response. However, parasites with the same pfcrt and pfmdr1 alleles exhibit a wide range of drug sensitivity, ...
ORGANISM(S): Plasmodium falciparum 
2008-11-06 | E-GEOD-10022 | biostudies-arrayexpress
UnknownClinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers.
Not available
S-EPMC5189630 | biostudies-literature
TranscriptomicsGenomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer.
MicroRNAs are small non-coding RNAs that regulate mRNA function. Recent studies have shown that microRNA expression is altered in tumors. We studied the expression of both microRNAs and mRNAs in 60 primary prostate tumors and 16 non-tumor prostate tissues to evaluate the involvement of microRNAs in ...
ORGANISM(S): Homo sapiens 
2008-08-05 | E-GEOD-8126 | biostudies-arrayexpress
TranscriptomicsAutocrine IL-1α mediates NF-κB activation by oncogenic ras in keratinocytes
Constitutively active RAS plays a central role in the development of skin cancer in the classical two stage skin carcinogenesis in mice and in a number of human cancers. Ras-mediated tumor formation is commonly associated with upregulation of cytokines and chemokines that mediate an inflammatory res...
ORGANISM(S): Mus musculus 
2011-08-28 | E-GEOD-22777 | biostudies-arrayexpress
UnknownDouble hit & double expressor lymphomas: a multicenter analysis of survival outcomes with CD19-directed CAR T-cell therapy.
Not available
S-EPMC11947441 | biostudies-literature
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