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ProteomicsA specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand
Heat shock protein-90 chaperone machinery is involved in the stability and activity of its client proteins. The chaperone function of Hsp90 is regulated by co-chaperones and post-translational modifications. Although structural evidence exists for Hsp90 interaction with clients, our understanding of...
ORGANISM(S): Homo sapiens (Human) 
2023-05-30 | PXD030486 | Pride
Hsp90 Co-chaperone Chaperone Glucocorticoid receptor Tsc1 Fnip1 Fnip2 Steroid hormone receptors 
TranscriptomicsControl of mammary stem cell function by steroid hormone signalling.
This SuperSeries is composed of the following subset Series: GSE20401: Mammary epithelial cell subpopulations from control and ovariectomized mice GSE20402: Mouse mammary epithelial cell subpopulations from pregnant and virgin mice Refer to individual Series
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22446 | biostudies-arrayexpress
TranscriptomicsMaintenance of Hormone Responsiveness in Luminal Breast Cancers by Suppression of Notch
Luminal breast cancers express estrogen (ER) and/or progesterone (PR) receptors and respond to hormone therapies. Basal-like “triple negative” (TN) cancers lack steroid receptors but are cytokeratin (CK) 5-positive and require chemotherapy. Here we show that over half of primary ER+PR+ breast cancer...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-31870 | biostudies-arrayexpress
TranscriptomicsGenomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer. [tumor samples RNA-seq]
Transcriptomic changes and estrogen and progesterone receptor binding in multiple ER+/PR+ models (eight ER+/PR+ patient tumors, various T47Ds, ZR75) and multiple ER+/PR-negative models (four ER+/PR- patient tuumors, PR-deficient T47D and MCF7 cells) treated with various hormone combinations. Results...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-80365 | biostudies-arrayexpress
GenomicsHormone Control Regions mediate steroid receptor-dependent genome organizations
Hormone Control Regions mediate steroid receptor-dependent genome organizations
PRJNA430222 | ENA
GenomicsGenomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer. [ChIP-seq]
Transcriptomic changes and estrogen and progesterone receptor binding in multiple ER+/PR+ models (eight ER+/PR+ patient tumors, various T47Ds, ZR75) and multiple ER+/PR-negative models (four ER+/PR- patient tuumors, PR-deficient T47D and MCF7 cells) treated with various hormone combinations. Results...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-80367 | biostudies-arrayexpress
TranscriptomicsGenomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer. [cell models RNA-seq]
Transcriptomic changes and estrogen and progesterone receptor binding in multiple ER+/PR+ models (eight ER+/PR+ patient tumors, various T47Ds, ZR75) and multiple ER+/PR-negative models (four ER+/PR- patient tuumors, PR-deficient T47D and MCF7 cells) treated with various hormone combinations. Results...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-80366 | biostudies-arrayexpress
GenomicsA distinct feed-forward mechanism between GREB1 and steroid receptors dictates hormone-dependent GREB1 action in endometrial function and dysfunction
A distinct feed-forward mechanism between GREB1 and steroid receptors dictates hormone-dependent GREB1 action in endometrial function and dysfunction
PRJNA1068689 | ENA
UnknownChemogenomics for steroid hormone receptors (NR3).
Not available
S-EPMC11790914 | biostudies-literature
GenomicsCharacterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
PRJNA412535 | ENA
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