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ProteomicsSTIM1 Translocation to The Nucleus Protects Cells from DNA Damage
DNA damage represents a challenge for cells as this damage must be eliminated to preserve cell viability and the transmission of genetic information. To reduce or eliminate unscheduled chemical modifications in genomic DNA, an extensive signaling network, known as the DNA damage response (DDR) pathw...
ORGANISM(S): Homo sapiens (Human) 
2023-12-22 | PXD041181 | Pride
Dna repair  double strand breaks  fanconi anemia  nucleus  stim1 
ProteomicsA longer isoform of Stim1 is a negative SOCE regulator but increases cAMP modulated NFAT signaling
Alternative splicing is a potent modifier of protein function. Stromal interaction molecule 1 (Stim1) is the essential activator of store-operated Ca2+ entry (SOCE) triggering activation of transcription factors. Here, we characterize Stim1A, a splice variant with an additional 31 amino acid domain ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD028974 | Pride
Orai Pip2 Splicing Nfat Pde8 
TranscriptomicsGene expression profile of STIM1 deficiency for cardiac remodeling in response to pressure overload by transverse aortic constriction (TAC)
STIM1 is a Ca2+ sensor of intracellular Ca2+ stores and essentially activates the Ca2+ entry channels of the plasma membrane. STIM1 is predicted to activate transient receptor potential canonical (TRPC) channels and Orai channels, and has a critical role in promoting the development of cardiac hyper...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-38733 | biostudies-arrayexpress
ProteomicsDisruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis and lean mass
STIM1 is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in store operated Ca2+ entry (SOCE), an ancient and ubiquitous signaling pathway. Whereas STIM1 is indispensable during development, its biological and metabolic functions in mature muscle ...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-30 | PXD030674 | JPOST Repository
GenomicsTranscriptome Stim1 R304W skeletal muscle
Transcriptome Stim1 R304W skeletal muscle
PRJNA743888 | ENA
ProteomicsStromal Interaction Molecule 1 Maintains Beta Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling
Loss of pancreatic Beta cell mass, identity, and function contribute to the development of diabetes. Here, we show that the endoplasmic reticulum (ER) calcium sensor, stromal interaction molecule 1 (STIM1), is critical for the maintenance of Beta cell function in female mice. When mice with Beta cel...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2022-07-20 | MSV000089927 | MassIVE
GenomicsExpression profile of select glucose and lipid metabolic genes mediated by STIM1 knockout, or STIM1 knockout plus Snail1 overexpression in SMMC7721 cells
Expression profile of select glucose and lipid metabolic genes mediated by STIM1 knockout, or STIM1 knockout plus Snail1 overexpression in SMMC7721 cells
PRJNA623315 | ENA
ProteomicsDIA-based quantitative proteomic analysis of U87 glioblastoma cells following optogenetic CRAC channel activation (LOV2-STIM1 + blue light stimulation)
Glioblastoma (GBM) is the most aggressive primary brain tumor. This dataset contains label-free quantitative proteomic profiles of U87 human glioblastoma cells transduced with the optogenetic construct LOV2-STIM1-mCherry, comparing cells kept in the dark (CTL, n = 3 biological replicates) with cells...
ORGANISM(S): Homo sapiens (Human) 
2026-08-23 | PXD082661 | Pride
Glioblastoma Dia Label-free quantitative proteomics Optogenetics Crac channel Pyroptosis Calcium signaling Timstof U87 Lov2-stim1 
GenomicsSTIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer [mRNAseq_siSTIM1_Thap]
STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer [mRNAseq_siSTIM1_Thap]
PRJNA638375 | ENA
GenomicsSTIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer [ChIPseq_siSTIM1_Thap]
STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer [ChIPseq_siSTIM1_Thap]
PRJNA638374 | ENA
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