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MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
TranscriptomicsRNA-seq of splenic natural killer cells from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Alteration of gene expression in natural killer cells triggers by HIF-1a loss.
ORGANISM(S): Mus musculus 
2022-08-22 | E-MTAB-12082 | biostudies-arrayexpress
TranscriptomicsRNA-seq of skin wounds at day 2 post wounding from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Global alterations of the early wound healing program by transcriptomics at a skin-wide level by deletion of HIF-1α in wound-infiltrating NK cells.
ORGANISM(S): Mus musculus 
2021-07-10 | E-MTAB-10699 | biostudies-arrayexpress
TranscriptomicsRNA-seq of skin lesions at day 2 post infection with Group A Streptococcus from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Changes of the transcriptional program in response to bacterial infections at a skin-wide level by deletion of HIF-1α in skin-lesions-infiltrating NK cells.
ORGANISM(S): Mus musculus 
2021-07-10 | E-MTAB-10700 | biostudies-arrayexpress
TranscriptomicsRNA-seq of colonic tissues from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Global alterations in gene expression in the colon triggered by HIF-1a loss in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11214 | biostudies-arrayexpress
TranscriptomicsRNA-seq of small intestine tissues from VHL(fl/fl) and Ncr1(Cre)VHL(fl/fl) mice
Global alterations in gene expression in the small intestine triggered by HIF-1a activation in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11212 | biostudies-arrayexpress
TranscriptomicsRNA-seq of small intestine tissues from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
Global alterations in gene expression in the small intestine triggered by HIF-1a loss in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11213 | biostudies-arrayexpress
TranscriptomicsRNA-seq of colonic tissues at day 4 post Dextran sulfate sodium (DSS)-induced colitis from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice.
Global alterations in gene expression in the damaged colon triggered by HIF-1a loss in NKp46+ cells.
ORGANISM(S): Mus musculus 
2021-12-10 | E-MTAB-11215 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of intestinal NKp46+ innate lymphoid cells (ILCs) from Hif1a(fl/fl) and Ncr1(Cre)Hif1a(fl/fl) mice
The unbiased approach to determine transcriptional profiles of sorted NKp46+ cells from the small intestine of WT and HIF-1α KO mice.
ORGANISM(S): Mus musculus 
2021-12-18 | E-MTAB-11238 | biostudies-arrayexpress
UnknownSingle-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Not available
S-EPMC9462075 | biostudies-literature
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