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TranscriptomicsTranscription profiling of human breast cancer brain metastases in a mouse xenograft model with vehicle of vorinostat treatment
Gene Expression Profiling of a Mouse Xenograft Model of â??Triple-Negativeâ?? Breast Cancer Brain Metastases With and Without Vorinostat Treatment. Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few...
ORGANISM(S): Homo sapiens 
2009-10-27 | E-GEOD-18544 | biostudies-arrayexpress
TranscriptomicsSkin gamma delta T cells in Obesity
Epithelial cells provide an initial line of defense against damage and pathogens in barrier tissues such as the skin; however this balance is disrupted in obesity and metabolic disease. Skin gamma delta T cells recognize epithelial damage and release cytokines and growth factors that facilitate wou...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22196 | biostudies-arrayexpress
TranscriptomicsLymph node CD4+ T cell and thioglycollate-elicited peritoneal macrophage expression data from naM-CM-/ve young and old SJL/J and SJL-ChrY^B10.S male mice
Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of ...
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-47437 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling reveals broad and differential effects of RBM3 on miRNA expression.
MicroRNAs (miRNAs) are a family of short, noncoding RNAs that regulate translation of mRNAs by mechanisms involving the binding of complementary sequences. The influence of miRNAs on the proteome and cellular events is extensive as they regulate an estimated 60% of the transcriptome and play key ro...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33519 | biostudies-arrayexpress
TranscriptomicsRNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress
Comparing the transcriptome of wildtype and kdm5 mutant flies in normal conditions revealed a total of 4787 genes that were significantly downregulated and thus require KDM5 for their activation, and 3269 upregulated genes that are normally repressed by KDM5 (p<0.05, FDR <0.05). Because kdm5 mutant...
ORGANISM(S): Drosophila melanogaster 
2015-12-22 | E-GEOD-70590 | biostudies-arrayexpress
UnknownPARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
Not available
S-SCDT-10_1038-S44319-024-00285-5 | biostudies-other
TranscriptomicsTranscriptional response of the marine pennate diatom Phaeodactylum tricornutum to Fe limitation
Diatoms, which are responsible for up to 40% of the 45 to 50 billion metric tons of organic carbon production each year in the sea, are particularly sensitive to Fe stress. Here we describe the transcriptional response of the pennate diatom Phaeodactylum tricornutum to Fe limitation using a partial ...
ORGANISM(S): Phaeodactylum tricornutum 
2010-05-27 | E-GEOD-8675 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pigmented and non-pigmented tubers of Solanum tuberosum
Transcriptional analysis of pigmented and non-pigmented potato tuber flesh using POCI 44k microarrays
ORGANISM(S): Solanum tuberosum 
2010-01-01 | E-TABM-787 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pigmented and non-pigmented tubers of Solanum tuberosum
Transcriptional analysis of pigmented and non-pigmented potato tuber flesh using POCI 44k microarrays
ORGANISM(S): Solanum tuberosum 
2010-01-01 | E-TABM-788 | biostudies-arrayexpress
TranscriptomicsEffects of tocilizumab versus methotrexate therapy on gene expression profiles in the early rheumatoid arthrtis synovium
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we investigated the global molecular effects of Tocilizumab, an approved humanized anti-IL6 Receptor antibody, versu...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-45867 | biostudies-arrayexpress
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