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MetabolomicsMuRF1-Related Metabolic Alterations in HL-1 Cardiomyocyte Induced by Cyclic Stretch
Not available
ORGANISM(S): Mus musculus 
ST000924 | MetabolomicsWorkbench
MetabolomicsC2C12 stretch cessation models muscle atrophy and anaplerotic changes in metabolism
Not available
ORGANISM(S): Mus musculus 
ST000431 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human bladder smooth muscle cells subjected to cyclic stretch-relaxation
The aim of the experiment was to determine the effect of cyclic stretch-relaxation ("stretch") on gene expression patterns in normal diploid human bladder smooth muscle cells. Cells plated on silicone elastomer bottomed 6-well culture dishes were grown to ~80% confluence, serum-depleted for 48h and ...
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1595 | biostudies-arrayexpress
TranscriptomicsEffect of prolonged stretch on transcript profile of human pregnant myometrium
Context: Increased uterine stretch appears to increase the risk of preterm labour, but the mechanism is unknown. Objectives: To identify a targetable mechanism mediating the effect of stretch on human myometrium. Design: Myometrial explants, prepared from biopsies obtained at elective caesarean de...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-31329 | biostudies-arrayexpress
TranscriptomicsChromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants (RNA-seq)
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic islets. Integrate...
ORGANISM(S): Homo sapiens 
2013-11-08 | E-GEOD-51310 | biostudies-arrayexpress
GenomicsChromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants (ChIP-seq)
Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome pro- filing in human pancreatic islets. Integra...
ORGANISM(S): Homo sapiens 
2013-11-08 | E-GEOD-51311 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neonatal ventricular cardiomyocytes (NRVCMs) stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM
Neonatal rat ventricular cardiomyocytes (NRVCMs) were stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM), both resulting in a similar degree of hypertrophy. Unstretched NRVCMs served as negative control. Affymetrix microarray analysis revealed 164 genes more than 2.0-fold up...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5996 | biostudies-arrayexpress
TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
ProteomicsPhosphoproteomic Network Analysis Reveals Molecular Mechanisms of Myometrial Stretch Response
Mechanical stress is a potent regulator of cell growth, contractility and gene regulation. Abnormal uterine distension during pregnancy increases the risk of preterm birth and likely activates crosstalk between multiple signaling networks with protein phosphorylation playing a critical role. Telomer...
ORGANISM(S): Homo sapiens (Human) 
2019-04-10 | PXD002538 | Pride
Human Cell culture Myometrium Uterus Distension Phosphoproteomic Stretch 
TranscriptomicsTranscription profiling of human A549 cell line activated with either cyclic stretch (20% elongation), tumor necrosis factor or lipopolysaccharide
Alveolar epithalial cells (A549) were used as a model of pulmonary parenchymal cell activation to quiery gene expression profile of activation with either cyclic stretch (20% elongation), TNF (20 ng/ml), LPS (1 mcg/ml) or TNF+STRETCH at both 1 and 4 hrs.
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1541 | biostudies-arrayexpress
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