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MetabolomicsCiprofloxacin-induced metabolic disruption and stringent response drives persistent small-colony variants in Staphylococcus aureus

Antibiotic treatment failure in Staphylococcus aureus infections is frequently associated with antimicrobial resistance or the emergence of small-colony variants (SCVs), a metabolically quiescent phenotype that complicates infection management. Here, we show that ciprofloxacin induces a stable SC...

2025-11-19 | MTBLS13343 | MetaboLights
MetabolomicsEnhanced fatty acid synthesis by Sigma28 in stringent responses contributes to multidrug resistance and biofilm formation in Helicobacter pylori

The metabolism of bacteria is closely associated with antibiotic resistance, yet the role of metabolism in the resistance of Helicobacter pylori remains unclear. In this study, we conducted integrated analysis using transcriptomics and non-targeted metabolomics to investigate the metabolic change...

2024-06-26 | MTBLS9981 | MetaboLights
ProteomicsThe opposite effects of stringent response on phage infection of Pseudomonas putida
Guanosine tetra- and pentaphosphate ((p)ppGpp) molecules are one of the key players in the stress response of bacteria. Accumulation of these alarmones activates the stringent response, usually triggered by different nutritional stresses. For Pseudomonas putida, there is only limited data available ...
ORGANISM(S): Pseudomonas putida Bacteria 
2026-01-23 | PXD070597 | Pride
Pseudomonas putida Stringent response Ppgpp 
TranscriptomicsThe Campylobacter jejuni stringent response controls specific stress survival and virulence-associated phenotypes
Campylobacter jejuni is a highly prevalent food-borne pathogen that causes diarrhoeal disease in humans. A natural zoonotic, it must overcome significant stresses both in vivo and during transmission despite the absence of several traditional stress response genes. Its ability to interact with and i...
ORGANISM(S): Campylobacter jejuni 
2005-08-27 | E-GEOD-3209 | biostudies-arrayexpress
GenomicsNitrogen regulatory protein C couples nitrogen stress response and stringent response in nitrogen starved Escherichia coli.
We show that NtrC couples the Ntr stress response and stringent response in N starved E. coli, which appears to be a conserved adaptive strategy employed by many bacteria to manage conditions of nutritional adversity. N starved Escherichia coli initiate the nitrogen regulation (Ntr) stress response ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2014-05-01 | E-MTAB-2211 | biostudies-arrayexpress
TranscriptomicsThe stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression
The stringent response is initiated by rapid (p)ppGpp synthesis, which leads to a profound reprogramming of gene expression in most bacteria. The stringent phenotype seems to be species specific and may be mediated by fundamentally different molecular mechanisms. In Staphylococcus aureus, (p)ppGpp s...
ORGANISM(S): Staphylococcus aureus 
2013-04-05 | E-GEOD-45617 | biostudies-arrayexpress
TranscriptomicsE. coli Isoleucine starvation and stringent response network
Transcription profiling of wild type, relA-, and relA-spoT-, crp-, dksA-, rpoS-, lrp- mutant strains of E. coli starved for isoleucine Bacteria comprehensively reorganize their global gene expression when faced with nutrient exhaustion. In Escherichia coli and other free-living bacteria, the alarmo...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2008-04-08 | E-GEOD-11087 | biostudies-arrayexpress
TranscriptomicsLactococcus lactis stringent response
The stringent response was defined in Lactococcus lactis through transcript profiling after the addition of a chemical inductor, the norvaline. Gene expression was measured in the exponential growth phase (reference sample) and at 1.6 h after norvaline addition. Four hundred and sixty one differenti...
ORGANISM(S): Lactococcus lactis 
2010-06-25 | E-GEOD-10254 | biostudies-arrayexpress
TranscriptomicsGlobal Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses.
In the intracellular pathogen Brucella spp., the activation of the stringent response, a global regulatory network providing rapid adaptation to a variety of growth-affecting stress conditions such as nutrient deficiency, is essential for replication in the host. A single, bi-functional enzyme Rsh c...
ORGANISM(S): Brucella suis 1330 
2013-07-08 | E-GEOD-44688 | biostudies-arrayexpress
TranscriptomicsVibrio cholerae stringent response
This study is an analysis of changes in gene expression during stringent response in Vibrio cholerae. V. cholerae cells in mid-log were treated with serine hydroxamate and gene expression was compared to untreated cells. Keywords: Stress response, stringent response
ORGANISM(S): Vibrio cholerae 
2006-12-28 | GSE6616 | GEO
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